After a few games early in the week on Thursday and Friday, NFL fans are ready for their first full slate of Sunday games of the season. The biggest game of the day is on Sunday Night Football and will feature the Buffalo Bills vs Baltimore Ravens matchup. The game is scheduled to begin on Sunday at 8:20 p.m. ET. It features two former MVP quarterbacks in Buffalo’s Josh Allen and Baltimore’s Lamar Jackson.
It is a matchup that will set the tone for the season for two teams that are expected to contend for the Super Bowl. Here is everything you need to know about the matchup.
Week 1 is HERE.
Top storylines to follow for #BALvsBUF: https://t.co/N5Jf66YzyP pic.twitter.com/AVFL3er755
— Buffalo Bills (@BuffaloBills) September 3, 2025
Buffalo Bills vs Baltimore Ravens Key Players to Watch
While analysts can point to the quarterbacks in any game as the key players, it is more the case in this matchup than in most others. Josh Allen and Lamar Jackson are widely viewed as two of the four best QBs in the league, alongside Kansas City’s Patrick Mahomes and Cincinnati’s Joe Burrow. Whenever these four QBs face off against each other, it is a big event. Fans are lucky to get to watch one of these matchups in Week 1.
Josh Allen is coming off an MVP season and will be looking to get his team off to a hot start in one of their toughest matchups of the season. Lamar Jackson is two seasons removed from his last MVP award and will also be looking to get off to a hot start with his squad.
Buffalo Bills vs Baltimore Ravens Odds and Betting Lines
Odds via FanDuel.
- Moneyline: Buffalo (+100), Baltimore (-118)
- Spread: Buffalo +1.5 points (-112), Baltimore -1.5 points (-108)
- Total: Over 50.5 points (-115), Under 50.5 points (-105)
Picks And Predictions For Buffalo Bills vs Baltimore Ravens
There is not a lot to go off of when looking ahead to this matchup. Both teams historically have done very well in the regular season under their current QBs. However, one of them will need to start the season with a loss.
While the Ravens are a slight betting favorite, we give the edge to the Bills. The game is being played in Buffalo, giving the Bills home-field advantage. The Bills were undefeated at home during the regular season last year. Conversely, the Ravens only had a 6-3 record on the road.
Best Bet: Buffalo Bills Moneyline (+100)
Read More:
- Lamar Jackson College Stats: Electric Louisville QB Put Up Insane Numbers To Become Youngest Ever Heisman Trophy Winner
- Where Did Lamar Jackson Play College Football? A Look Back at the NFL MVP’s Accolades
- Revisiting the 2018 NFL Draft: Why the Buffalo Bills Picked Josh Allen
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