College football Week 10 is upon us, and by this time of year, we normally have a solid idea of who’s good, bad, and downright ugly. However, in this wildest of seasons, predicting who will win each week isn’t the easiest of tasks. Nonetheless, we’ve predicted the winner and scoreline of every Week 10 game.
We compiled our college football predictions for Week 10 using the College Football Network Playoff Predictor, and you can too! Predict a conference, predict every game, or simulate the entire season to discover which 12 teams will make the 2024-2025 College Football Playoff. Get started right now!
Ohio State vs. Penn State Prediction
- Prediction: Ohio State 33, Penn State 23
- Betting Lines: Ohio State -4
- TV Channel: Fox
Duke vs. Miami (FL) Prediction
- Prediction: Duke 15, Miami (FL) 30
- Betting Lines: Miami (FL) -20
- TV Channel: ABC
Ole Miss vs. Arkansas Prediction
- Prediction: Ole Miss 33, Arkansas 21
- Betting Lines: Ole Miss -6.5
- TV Channel: ESPN
Air Force vs. Army Prediction
- Prediction: Air Force 21, Army 35
- Betting Lines: Army -23.5
- TV Channel: CBS
Minnesota vs. Illinois Prediction
- Prediction: Minnesota 19, Illinois 33
- Betting Lines: Minnesota -2
- TV Channel: FS1
Northwestern vs. Purdue Prediction
- Prediction: Northwestern 19, Purdue 33
- Betting Lines: Northwestern -1.5
- TV Channel: Big Ten Network
Stanford vs. NC State Prediction
- Prediction: Stanford 21, NC State 40
- Betting Lines: NC State -10
- TV Channel: ACC Network
Virginia Tech vs. Syracuse Prediction
- Prediction: Virginia Tech 27, Syracuse 31
- Betting Lines: Virginia Tech -4
- TV Channel: The CW Network
Buffalo vs. Akron Prediction
- Prediction: Buffalo 40, Akron 20
- Betting Lines: Buffalo -1
- TV Channel: CBS Sports Network
Toledo vs. Eastern Michigan Prediction
- Prediction: Toledo 21, Eastern Michigan 10
- Betting Lines: Toledo -8
- TV Channel: ESPNU
Memphis vs. UTSA Prediction
- Prediction: Memphis 39, UTSA 20
- Betting Lines: Memphis -8
- TV Channel: ESPN2
Vanderbilt vs. Auburn Prediction
- Prediction: Vanderbilt 40, Auburn 21
- Betting Lines: Auburn -6.5
- TV Channel: SEC Network
Maine vs. Oklahoma Prediction
- Prediction: Maine 21, Oklahoma 44
- Betting Lines: No line available
- TV Channel: ESPN+
Old Dominion vs. Appalachian State Prediction
- Prediction: Old Dominion 30, Appalachian State 13
- Betting Lines: Old Dominion -2.5
- TV Channel: ESPN+
Tulsa vs. UAB Prediction
- Prediction: Tulsa 38, UAB 19
- Betting Lines: UAB -3.5
- TV Channel: ESPN+
Oregon vs. Michigan Prediction
- Prediction: Oregon 31, Michigan 17
- Betting Lines: Oregon -14.5
- TV Channel: CBS/Paramount+
Florida vs. Georgia Prediction
- Prediction: Florida 21, Georgia 31
- Betting Lines: Georgia -16.5
- TV Channel: ABC
Texas Tech vs. Iowa State Prediction
- Prediction: Texas Tech 24, Iowa State 37
- Betting Lines: Iowa State -14.5
- TV Channel: ESPN
Indiana vs. Michigan State Prediction
- Prediction: Indiana 28, Michigan State 10
- Betting Lines: Indiana -7
- TV Channel: Peacock
Kansas State vs. Houston Prediction
- Prediction: Kansas State 39, Houston 24
- Betting Lines: Kansas State -13
- TV Channel: Fox
UCLA vs. Nebraska Prediction
- Prediction: UCLA 24, Nebraska 38
- Betting Lines: Nebraska -7.5
- TV Channel: Big Ten Network
North Carolina vs. Florida State Prediction
- Prediction: North Carolina 34, Florida State 17
- Betting Lines: North Carolina -2
- TV Channel: ACC Network
Arizona vs. UCF Prediction
- Prediction: Arizona 26, UCF 23
- Betting Lines: UCF -6.5
- TV Channel: FS1
Middle Tennessee vs. UTEP Prediction
- Prediction: Middle Tennessee 30, UTEP 33
- Betting Lines: UTEP -3
- TV Channel: CBS Sports Network
Louisiana-Monroe vs. Marshall Prediction
- Prediction: Louisiana-Monroe 40, Marshall 27
- Betting Lines: Marshall -10.5
- TV Channel: ESPN+
Wyoming vs. New Mexico Prediction
- Prediction: Wyoming 34, New Mexico 31
- Betting Lines: New Mexico -7
- TV Channel: TruTV/Max
Coastal Carolina vs. Troy Prediction
- Prediction: Coastal Carolina 26, Troy 14
- Betting Lines: Coastal Carolina -4.5
- TV Channel: ESPN+
Navy vs. Rice Prediction
- Prediction: Navy 37, Rice 21
- Betting Lines: Navy -13
- TV Channel: ESPN2
UMass vs. Mississippi State Prediction
- Prediction: UMass 17, Mississippi State 35
- Betting Lines: Mississippi State -18
- TV Channel: SEC Network
Arizona State vs. Oklahoma State Prediction
- Prediction: Arizona State 17, Oklahoma State 21
- Betting Lines: Arizona State -1
- TV Channel: FS1
Hawaii vs. Fresno State Prediction
- Prediction: Hawaii 20, Fresno State 34
- Betting Lines: Fresno State -13
- TV Channel: Spectrum Sports
Texas A&M vs. South Carolina Prediction
- Prediction: Texas A&M 24, South Carolina 13
- Betting Lines: Texas A&M -3.5
- TV Channel: ABC
Louisville vs. Clemson Prediction
- Prediction: Louisville 17, Clemson 34
- Betting Lines: Clemson -11.5
- TV Channel: ESPN
Wisconsin vs. Iowa Prediction
- Prediction: Wisconsin 27, Iowa 31
- Betting Lines: Iowa -3.5
- TV Channel: NBC
USC vs. Washington Prediction
- Prediction: USC 14, Washington 27
- Betting Lines: USC -2.5
- TV Channel: Big Ten Network
Georgia Southern vs. South Alabama Prediction
- Prediction: Georgia Southern 23, South Alabama 40
- Betting Lines: South Alabama -6
- TV Channel: ESPNU
Kentucky vs. Tennessee Prediction
- Prediction: Kentucky 14, Tennessee 27
- Betting Lines: Tennessee -16
- TV Channel: SEC Network
Pittsburgh vs. SMU Prediction
- Prediction: Pittsburgh 34, SMU 27
- Betting Lines: SMU -7.5
- TV Channel: ACC Network
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TCU vs. Baylor Prediction
- Prediction: TCU 27, Baylor 14
- Betting Lines: Baylor -3
- TV Channel: ESPN2
Colorado State vs. Nevada Prediction
- Prediction: Colorado State 37, Nevada 23
- Betting Lines: Colorado State -1
- TV Channel: CBS Sports Network
New Mexico State vs. Florida International Prediction
- Result: New Mexico State 13, Florida International 34
- Prediction: New Mexico State 24, Florida International 40
Louisiana vs. Texas State Prediction
- Result: Louisiana 23, Texas State 17
- Prediction: Louisiana 33, Texas State 17
Louisiana Tech vs. Sam Houston Prediction
- Result: Louisiana Tech 3, Sam Houston 9
- Prediction: Louisiana Tech 14, Sam Houston 35
Jacksonville State vs. Liberty Prediction
- Result: Jacksonville State 31, Liberty 21
- Prediction: Jacksonville State 17, Liberty 34
Kennesaw State vs. Western Kentucky Prediction
- Result: Kennesaw State 14, Western Kentucky 31
- Prediction: Kennesaw State 14, Western Kentucky 31
Tulane vs. Charlotte Prediction
- Result: Tulane 34, Charlotte 3
- Prediction: Tulane 37, Charlotte 27
Georgia State vs. UConn Prediction
- Result: Georgia State 27, UConn 34
- Prediction: Georgia State 33, UConn 21
South Florida vs. Florida Atlantic Prediction
- Result: South Florida 44, Florida Atlantic 21
- Prediction: South Florida 27, Florida Atlantic 17
San Diego State vs. Boise State Prediction
- Result: San Diego State 24, Boise State 56
- Prediction: San Diego State 21, Boise State 35
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