Finding the right defense/special teams (DST) in fantasy football can often swing a matchup, and with several offenses in shambles entering Week 6 of the 2025 NFL season, there are plenty of exploitable opportunities. Here’s a look at which defenses you should trust and which you should keep far away from your starting lineup this week.
Defenses To Start
Denver Broncos @ New York Jets
The Broncos have quietly developed into one of the league’s most consistent defensive units. They lead the NFL in pressure rate (33.4%) and rank top five in opponent third-down conversion rate. Against a Jets offense that has turned the ball over seven times in the past three games, Denver’s front seven should have a great game. This is one of the best DST starts of Week 6.
Green Bay Packers vs. Cincinnati Bengals
Green Bay’s defense is trending upward, largely thanks to a front seven generating steady pressure. With Cincinnati’s offense ranking bottom five in passing efficiency, the Packers’ ability to force turnovers makes them an intriguing high-upside play for Week 6.
Pittsburgh Steelers vs. Cleveland Browns
Fresh off their bye, Pittsburgh’s defense looks rested and ready to cause chaos. The Steelers have forced nine turnovers through four games and remain one of the most opportunistic units in football. With Cleveland’s offensive line struggling to keep their quarterback upright, T.J. Watt and company are a must-start.
Philadelphia Eagles @ New York Giants
The Eagles’ defense has returned to its dominant form, ranking top five in sacks and turnovers. They’ll face a Giants offense missing key starters on the offensive line, which has allowed an average of 3.8 sacks per game. Expect the Eagles’ secondary is primed to make plays against an inexperienced quarterback.
Defenses To Sit
Buffalo Bills vs. Atlanta Falcons
Buffalo’s defense has not looked the same since early-season injuries began piling up. They’ve allowed at least 24 points in three straight games and lack the consistent pressure needed to slow down Atlanta’s run-heavy offense.
New Orleans Saints vs. New England Patriots
The Saints’ defense has been inconsistent at best, giving up chunk plays on the ground and through the air. New England’s offense isn’t explosive, but it’s disciplined enough to limit turnovers, making this a low-upside DST play.
Bottom Line
Week 6 presents several favorable matchups for fantasy managers streaming defenses. Denver is the clear top play, combining elite pass-rush production with a mistake-prone opponent. Pittsburgh, Philadelphia, and Green Bay all offer safe floors with legitimate upside. On the flip side, Buffalo and New Orleans are defenses to fade until they prove they can generate turnovers again.
Read More:
NFL Fantasy Start ‘Em Sit ‘Em Flex: Top Players To Help You Win Week 5 Matchup Ft. J.K. Dobbins
College Sports Network has you covered with the latest news, analysis, insights, and trending stories in college football, men’s college basketball, women’s college basketball, and college baseball!
