After a hard-fought opener, the Jets travel to Orchard Park to face a Bills squad dealing with several key injuries. Buffalo will be without DT Ed Oliver, and both teams have several players listed on their injury reports. Both teams are coming off close games in Week 1 where we saw the Bills come back to beat the Ravens and the Jets fall to the Steelers.
Jets vs Bills Projected Starting Lineup for Week 2
New York Jets Starting Lineup
Offense
| Position | Player |
| QB | Justin Fields |
| RB | Breece Hall |
| WR1 | Garrett Wilson |
| WR2 | Allen Lazard |
| WR3 | Tyler Johnson |
| TE | Mason Taylor |
| LT | Olu Fashanu |
| LG | John Simpson |
| C | Josh Myers |
| RG | Joe Tippmann |
| RT | Armand Membou |
Defense
| Position | Player |
| DE | Jermaine Johnson |
| DT | Quinnen Williams |
| DT | Harrison Phillips |
| DE | Will McDonald IV |
| LB | Marcelino McCary-Ball |
| LB | Quincy Williams |
| LB | Jamien Sherwood |
| CB | Sauce Gardner |
| CB | Brandon Stephens |
| FS | Andre Cisco |
| SS | Tony Adams |
Specialists
| Position | Player |
| K | Nick Folk |
| P | Austin McNamara |
| LS | Thomas Hennessy |
| KR/PR | Isaiah Davis |
Buffalo Bills Starting Lineup
Offense
| Position | Player |
| QB | Josh Allen |
| RB | James Cook |
| WR1 | Keon Coleman |
| WR2 | Khalil Shakir |
| WR3 | Joshua Palmer |
| TE | Dalton Kincaid |
| LT | Dion Dawkins |
| LG | David Edwards |
| C | Connor McGovern |
| RG | O’Cyrus Torrence |
| RT | Spencer Brown |
Defense
| Position | Player |
| DE | Greg Rousseau |
| DT | DaQuan Jones |
| DT | Zion Logue |
| DE | Joey Bosa |
| LB | Terrel Bernard |
| LB | Dorian Williams |
| LB | Joe Andreessen |
| CB | Tre’Davious White |
| CB | Christian Benford |
| FS | Cole Bishop |
| SS | Taylor Rapp |
Specialists
| Position | Player |
| K | Matt Prater |
| P | Cameron Johnston |
| LS | Reid Ferguson |
| KR/PR | Brandon Codrington |
Jets vs Bills Depth Chart for Week 2
New York Jets Depth Chart
| Position | 1st | 2nd | 3rd |
| QB | Justin Fields | Tyrod Taylor | — |
| RB | Breece Hall | Braelon Allen | Isaiah Davis |
| WR1 | Garrett Wilson | Josh Reynolds | Arian Smith |
| WR2 | Allen Lazard | Tyler Johnson | — |
| WR3 | Tyler Johnson | Isaiah Williams | — |
| TE | Mason Taylor | Jeremy Ruckert | Stone Smartt |
| LT | Olu Fashanu | Max Mitchell | — |
| LG | John Simpson | Xavier Newman | — |
| C | Josh Myers | Gus Hartwig | — |
| RG | Joe Tippmann | — | — |
| RT | Armand Membou | Chukwuma Okorafor | — |
Defense
| Position | 1st | 2nd | 3rd |
| DE | Jermaine Johnson | Micheal Clemons | — |
| DT | Quinnen Williams | Jay Tufele | — |
| DT | Harrison Phillips | Jowon Briggs | — |
| DE | Will McDonald IV | Tyler Baron | — |
| LB | Marcelino McCrary-Ball | Cam Jones | — |
| LB | Quincy Williams | — | |
| LB | Jamien Sherwood | Kiki Mauigoa | — |
| CB | Sauce Gardner | Qwan’tez Stiggers | — |
| CB | Brandon Stephens | Tony Adams | — |
| FS | Andre Cisco | Malachi Moore | — |
| SS | Tony Adams | Isaiah Oliver | — |
Buffalo Bills Depth Chart
| Position | 1st | 2nd | 3rd |
| QB | Josh Allen | Mitchell Trubisky | — |
| RB | James Cook | Ray Davis | Ty Johnson |
| WR1 | Keon Coleman | Curtis Samuel | — |
| WR2 | Khalil Shakir | Tyrell Shavers | — |
| WR3 | Joshua Palmer | Marquez Stevenson | — |
| TE | Dalton Kincaid | Dawson Knox | Jackson Hawes |
| LT | Dion Dawkins | Ryan Van Demark | — |
| LG | David Edwards | Alec Anderson | — |
| C | Connor McGovern | Sedrick Van Pran | — |
| RG | O’Cyrus Torrence | Kevin Jarvis | — |
| RT | Spencer Brown | Chase Lundt | — |
Defense
| Position | 1st | 2nd | 3rd |
| DE | Greg Rousseau | AJ Epensea | — |
| DT | DaQuan Jones | T.J. Sanders | — |
| DT | Zion Logue | — | — |
| DE | Joey Bosa | Landon Jackson | — |
| LB | Terrel Bernard | Joe Andreessen | — |
| LB | Matt Milano | Shaq Thompson | — |
| LB | Dorian Williams | Keonta Jenkins | — |
| CB | Tre’Davious White | Ja’Marcus Ingram | — |
| CB | Christian Benford | Dorian Strong | — |
| FS | Cole Bishop | Damar Hamlin | — |
| SS | Taylor Rapp | Cam Lewis | — |
How to Watch Jets vs Bills
The game will be on Sunday, September 14, 2025 at 1:00 PM ET. It will be played at Highmark Stadium in Buffalo, New York. The broadcast will available on CBS, and streaming via Paramount+ or NFL+ depending on region.
Prediction
Both offenses should be going back and forth in what should be an entertaining game. After New York’s defeat last week, they should come out of the gate looking to win this game early. Although, Josh Allen and the high-powered Bills offense should give the Bills the edge down the stretch.
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