Miller Moss has been one of Louisville’s most important players this season. After transferring in and earning the starting quarterback job, he has started every game and helped guide the Cardinals through a competitive ACC slate.
His consistency has been a major asset. Moss has provided rhythm to an offense that needed stability early in the year, and he has handled pressure situations well, including late-game moments where his accuracy and composure stood out.
Louisville’s season has had its highs and lows, but Moss has remained the anchor of the unit. The Cardinals have stayed competitive in large part because of his efficiency, leadership, and ability to push the ball downfield.
He has also shown good command of the scheme, which made him a natural fit for what Louisville wanted offensively. But as the team prepares for its matchup against SMU, things have taken a sharp turn.
According to Matt Zenitz of CBS Sports, Moss is trending toward not playing due to an undisclosed injury. Louisville has officially listed him as questionable, but reports suggest the team is preparing to move forward without him today.
“It’s currently trending toward Louisville QB Miller Moss missing tomorrow’s game vs. SMU due to an injury and redshirt freshman Deuce Adams making the start for the Cardinals, sources tell @CBSSports. Louisville and SMU both enter the game 7-3,” Zenitz posted on X.
It’s currently trending toward Louisville QB Miller Moss missing tomorrow’s game vs. SMU due to an injury and redshirt freshman Deuce Adams making the start for the Cardinals, sources tell @CBSSports.
Louisville and SMU both enter the game 7-3. pic.twitter.com/YTbMwr8mNL
— Matt Zenitz (@mzenitz) November 22, 2025
Losing your starting quarterback this late in the season is always a major storyline, and Moss’s potential absence significantly shifts expectations for the offense. His importance cannot be overstated.
Louisville may now need to rely on redshirt freshman Deuce Adams, who has shown potential but has nowhere near Moss’s game reps or experience. If Moss is indeed sidelined, the Cardinals will have to adjust quickly and lean more heavily on their run game, short-passing concepts, and defensive support.
What Happened to Miller Moss?
The biggest challenge with this situation is the lack of clarity. Louisville has not revealed the specific nature of Moss’s injury. He appeared in the team’s previous game against Clemson and played a full workload, throwing for over 200 yards and adding a rushing touchdown.
There was no obvious moment in that matchup when Moss appeared shaken up or in visible discomfort. In the days that followed, Louisville released its injury reports for the week.
Moss was listed as questionable with no details attached. That immediately raised concerns, because starting quarterbacks are normally listed with some specificity when possible. The absence of information hinted at a non-minor issue.
The timeline suggests the injury was discovered after the Clemson matchup, possibly during evaluation or midweek preparation. Without the team offering further information, the situation remains unclear. What is clear, however, is that Louisville is preparing to take the field without one of its most important players.
Read More:
QB Miller Moss Gets GF Sofia Hildebrand’s Fired-Up 3-Word Message Before Louisville Debut
Analyst Pinpoints Harsh Reality Behind Miller Moss’ Exit From Lincoln Riley’s USC To ACC Program
Who Are Miller Moss’ Parents? All We Know About USC Transfer QB’s Personal Life
College Sports Network has you covered with the latest news, analysis, insights, and trending stories in college football, men’s college basketball, women’s college basketball, and college baseball!
