Men’s March Madness Final Four Predictions: Analyzing the Matchups and Who’s Set To Advance

The 2025 NCAA Tournament has delivered historic results, with all four No. 1 seeds advancing to the Final Four for the first time since 2008. Duke, Houston, Auburn, and Florida will battle at the Alamodome in San Antonio on April 5.

Each team brings an impressive tournament resume featuring dominant wins and clutch performances that have showcased why they were awarded the top rating in their regions.

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College Sports Network’s CBB Power Rankings analyze every team’s strength in a proprietary ranking system, from No. 1 to No. 364. Who are the real contenders?

Final Four Schedule

College basketball fans can anticipate fascinating tactical battles as contrasting styles collide on the sport’s biggest stage. Duke’s towering lineup featuring projected No. 1 NBA Draft pick Cooper Flagg faces Houston’s suffocating defense.

At the same time, SEC rivals Auburn and Florida reignite their conference rivalry, with Wooden Award contender Johni Broome facing Walter Clayton Jr.’s offensive firepower and the nation’s most efficient offense.

The complete Final Four weekend at the Alamodome in San Antonio, Texas, includes:

Friday, April 4, 2025 – Practice Day (Free Admission)

Auburn: 1:00 p.m. – 1:50 p.m. ET
Florida:  2:00 p.m. – 2:50 p.m. ET
Duke: 3:00 p.m. – 3:50 p.m. ET
Houston: 4:00 p.m. – 4:50 p.m. ET

Saturday, April 5, 2025 – Semifinal Games

Auburn vs. Florida: 6:09 p.m. ET (5:09 p.m. CT)
Duke vs. Houston: 8:49 p.m. ET (7:49 p.m. CT)
TV Broadcast: CBS
Streaming: March Madness Live

Final Four Analysis

Duke vs. Houston Matchup

The East Region champion Duke (35-3) has been utterly dominant throughout the tournament, crushing opponents by an average margin of 23.5 points behind the fully healthy Cooper Flagg.

His 16-point performance against Alabama in the Elite Eight proved that his ankle injury from the ACC Tournament is no longer limiting his explosive athleticism and versatility.

Houston (35-4) has the nation’s top-ranked defense, which completely neutralized Tennessee, holding them to just 50 points in their Elite Eight victory.

The Cougars have surprisingly become an elite three-point shooting team, connecting at 39.8%, led by LJ Cryer and Milos Uzan, who provide the offensive spark to complement their defensive identity.

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Duke’s imposing size advantage, as their shortest starter is 6’6″, and a balanced scoring attack should ultimately prevail against Houston’s defensive pressure. While the Cougars will keep it competitive with timely threes and defensive stops, Flagg’s star power and Duke’s superior depth give them the edge in a physical contest.

Prediction: Duke wins 74-68, narrowly covering the 4.5-point spread.

Auburn vs. Florida Matchup

SEC rivals Auburn (33-5) and Florida (34-4) meet again after the Gators’ 90-81 road victory in February. Florida enters on a 10-game winning streak showcasing resilience in their Elite Eight comeback against Texas Tech, where they erased a 10-point deficit in the final five minutes to secure their Final Four berth.

Auburn’s tournament path began with some shaky performances, but they’ve found their rhythm behind Wooden Award contender Johni Broome, whose stats are 18.6 PPG, 10.6 RPG, and 2.6 BPG.

The Tigers’ shot-blocking prowess and deep 10-man rotation provide sustainability for their aggressive defensive style.

Florida’s elite offense, ranked No. 1 in efficiency per KenPom, led by Walter Clayton Jr., should ultimately overcome Auburn’s interior dominance. The Gators’ prior success against the Tigers and their perimeter shooting ability, as they hit 13 threes in their regular season matchup, gives them the edge.

Prediction: Florida prevails 82-78 in what should be an up-tempo high-scoring affair.

Looking ahead to Monday’s championship, Duke’s combination of elite talent, size, and versatility likely gives them the edge against Florida in a potential final.

Flagg’s ability to impact both ends of the court could be the difference maker in what would be a fitting conclusion to a tournament that, while chalk-heavy with all No. 1 seeds advancing, has still delivered memorable performances and dramatic finishes along the way.

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This historic all-No. 1 seed Final Four promises championship-level basketball at every turn. From Houston’s defensive masterclass to Duke’s NBA-ready roster and Auburn’s interior dominance to Florida’s offensive fireworks, each team brings legitimate title credentials to San Antonio.

Whether Flagg cements his legacy, Houston captures their elusive first title or an SEC program cuts down the net, the Alamodome will host basketball royalty in what should be a weekend to remember.

Don’t miss a moment of March Madness! Download your 2025 NCAA Tournament printable bracket and stay on top of every game, matchup, and Cinderella story. Get yours now!

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