Week 6 of the college football season is here. Seasoned fans know that also means conference play is starting to become more prominent. As each game plays out, the conference championship layout will start to become clearer. While fans, media, and sportsbooks are starting to get an idea of which teams are good and which are not, sharp bettors can still find some good lines. Here is a look at the best bets for Week 6.
Best Bets for Week 6 of the 2025 College Football Season
Top Moneyline Underdogs
When looking at games featuring Top 25 ranked teams, most of the betting lines set by sportsbooks are good. However, there are a few favorites that could be primed for an upset. One is No. 10-ranked Alabama, which is playing against No. 16-ranked Vanderbilt. The Commodores upset the Crimson Tide last year, and now they are +310 underdogs again. With the Crimson Tide looking vulnerable, it could be an interesting bet to make.
TRUE OR FALSE
Diego Pavia and the Vanderbilt Commodores will upset Alabama again this week pic.twitter.com/cfMJNW224P
— CFBTalkDaily (@CFBTalkDaily) October 1, 2025
Another interesting option is Florida as a +220 underdog against No. 9-ranked Texas. Quarterback Arch Manning has been underwhelming in his performance, as have the Longhorns as a whole. While the Gators have not been world beaters, they look better than their 1-3 record indicates, given their tough schedule. So, this could be an interesting spot to place a bet.
Spread Bets
When looking at the spread betting options, one game stands out. The No. 2-ranked Oregon Ducks host the No. 8-ranked Indiana Hoosiers on Saturday. Both teams are undefeated, but the Ducks are still a 10.5-point favorite. Even though we think the Ducks will win, we think -112 on the Hoosiers to cover the spread is a great wager.
Another option is the matchup between No. 3-ranked Miami and No. 18-ranked Florida State. Miami is only a 4.5-point favorite, and we think that is far too little. The odds to place a bet are -106, which we think are fantastic.
Player Props
Vanderbilt QB Diego Pavia seems to rise to the occasion when the pressure is on. So, we think he could have a big game against Alabama on Saturday. We love him to score over 1.5 passing TDs at +134. Pavis over 272.5 passing and rushing yards at -114 odds is also a solid bet.
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