Running back Omarion Hampton was the 22nd pick in the 2025 NFL draft, selected by the Los Angeles Chargers. He has had a strong start to his career, rushing for 314 yards and two TDs on 66 carries. However, Week 5 resulted in the first speed bump of his NFL career. He suffered an ankle injury and was seen in a walking boot after the game. As a result, he will not be available for the Chargers when they play the Miami Dolphins on Sunday.
Omarion Hampton just left the locker room with a walking boot on his left ankle.
— Daniel Popper (@danielrpopper) October 5, 2025
What Happened to Omarion Hampton?
Hampton injured his ankle on a play late in the third quarter against Washington on Sunday. Quarterback Justin Herbert took the snap and faked a handoff to Hampton. Herbert rolled to his right as Hampton sprinted into the flat of the field. However, as Hampton accelerated, he tripped over the foot of a Washington linebacker. When he got up, he was limping and exited the game. He was seen in the blue medical tent shortly after. He was unable to return to the game.
Is Omarion Hampton Playing Week 6?
No, Omarion Hampton will not play for the Chargers in Week 6. He is expected to be out for at least four weeks as he was placed on the injured reserve. The exact nature of his injury has not been revealed, but it is speculated to be a bruise or strain.
Omarion Hampton Fantasy Outlook
Omarion Hampton’s injury is not speculated to be significant. However, that will not help fantasy owners for the next few weeks. Before his injury-shortened game this past week, Hampton had posted back-to-back top 10 finishes among running backs in fantasy in Weeks 3 and 4. As a result, fantasy owners will need to find a way to replace his production for the next month or so.
The Chargers have suffered serious injuries this year at the running back position. Najee Harris was already out for the year, and now Hampton is out for at least a month.
Hassan Haskins is next on the depth chart, followed by Kimani Vidal. Both are likely to see a serious uptick in carries in the coming weeks. So, they could emerge as viable fantasy options.
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