The 2025 season has proven to be very injury-heavy for the San Francisco 49ers, with the injury bug biting them hard. The same can be said for their next opponents, the Carolina Panthers, who have suffered plenty of injuries as well this season. This begs the question of who will be playing and who is injured for this clash?
San Francisco 49ers vs. Carolina Panthers Injury Report
49ers
Brock Purdy – Playing
Niners QB1 Brock Purdy may have missed a lot of games this season due to turf toe, but he has been back for a few games now and is expected to play again against the Panthers.
Ricky Pearsall – Playing
Another player who missed much of the season due to injury, Pearsall is now actually back and will be playing for the Niners in Week 12.
Brandon Aiyuk – Out
Yes, his guaranteed money for 2026 has been voided, but Aiyuk is still signed with the Niners for this year. He has not played a single game yet and is expected to still be out.
Panthers
Rico Dowdle – Playing
The Panthers have had a running back problem during the first half of their season, as their RB1, Dowdle, and RB2, Chuba Hubbard, were both out with injuries. Now both are back and are expected to play vs. the Niners.
Christian Rozeboom – Out
The Panthers’ starting linebacker has been ruled out against the Niners thanks to a hip and hamstring injury.
Trent Taylor – Injured Reserve
This Panthers wide receiver is expected to miss the rest of the season after receiving season-ending surgery for a shoulder injury.
San Francisco 49ers vs. Carolina Panthers Depth Chart
49ers
| Starter | 2nd | 3rd | 4th | |
| QB | Brock Purdy | Mac Jones | Kurtis Rourke O | – |
| RB | Christian McCaffrey | Brian Robinson Jr. | Isaac Guerendo | Jordan James |
| WR | Jauan Jennings | Kendrick Bourne | Brandon Aiyuk O | – |
| WR | Ricky Pearsall | Skyy Moore | Jacob Cowing IR | – |
| WR | Demarcus Robinson | Jordan Watkins | Trent Taylor IR | – |
| TE | George Kittle | Luke Farrell | Jake Tonges | – |
| FB | Kyle Juszczyk | – | – | – |
| LT | Trent Williams | Spencer Burford | – | – |
| LG | Ben Bartch | Spencer Burford | Connor Colby | – |
| C | Jake Brendel | Matt Hennessy | – | – |
| RG | Dominick Puni | – | – | – |
| RT | Colton McKivitz | Austen Pleasants | – | – |
| LDE | Bryce Huff | Keion White | Nick Bosa IR | Tarron Jackson IR |
| LDT | Kalia Davis | Kevin Givens | – | – |
| RDT | Alfred Collins | Jordan Elliott | CJ West | – |
| RDE | Sam Okuayinonu | Robert Beal Jr. D | Clelin Ferrell | Yetur Gross-Matos IR |
| WLB | Dee Winters | Nick Martin | – | – |
| MLB | Tatum Bethune O | Curtis Robinson | Fred Warner IR | – |
| SLB | Luke Gifford Q | – | – | – |
| LCB | Renardo Green | Tre Tomlinson IR | – | – |
| SS | Ji’Ayir Brown | Jason Pinnock | – | – |
| FS | Malik Mustapha | Marques Sigle | Siran Neal | – |
| RCB | Deommodore Lenoir | Darrell Luter Jr. | Jakob Robinson IR | – |
| NB | Upton Stout | Chase Lucas | – | – |
| PK | Eddy Pineiro O | – | – | – |
| P | Thomas Morstead | – | – | – |
| H | Thomas Morstead | – | – | – |
| PR | Skyy Moore | Jordan Watkins | Jacob Cowing IR | – |
| KR | Skyy Moore | Isaac Guerendo | – | – |
| LS | Jon Weeks | – | – | – |
Panthers
| Starter | 2nd | 3rd | 4th | |
| QB | Bryce Young | Andy Dalton | – | – |
| RB | Rico Dowdle | Chuba Hubbard | Trevor Etienne | Jonathon Brooks O |
| WR | Tetairoa McMillan | Jimmy Horn Jr. | David Moore IR | – |
| WR | Xavier Legette | Brycen Tremayne | – | – |
| WR | Jalen Coker | Hunter Renfrow | – | – |
| TE | Ja’Tavion Sanders | Tommy Tremble | Mitchell Evans | James Mitchell |
| LT | Ikem Ekwonu | Yosh Nijman | – | – |
| LG | Damien Lewis | Austin Corbett | – | – |
| C | Cade Mays O | Austin Corbett | Nick Samac | – |
| RG | Chandler Zavala | Jake Curhan | Robert Hunt IR | Brady Christensen IR |
| RT | Taylor Moton | Yosh Nijman | – | – |
| LDE | Tershawn Wharton | Bobby Brown III | Popo Aumavae IR | – |
| LDT | A’Shawn Robinson | Bobby Brown III | Cam Jackson | – |
| RDT | Derrick Brown | LaBryan Ray | Jared Harrison-Hunte | – |
| RDE | Nic Scourton | Trevis Gipson | Patrick Jones II IR | – |
| WLB | Christian Rozeboom O | Maema Njongmeta | Bam Martin-Scott | – |
| MLB | Trevin Wallace O | Claudin Cherelus | – | – |
| SLB | D.J. Wonnum | Princely Umanmielen | Thomas Incoom | – |
| LCB | Mike Jackson | Akayleb Evans | Damarri Mathis IR | – |
| SS | Tre’von Moehrig | Demani Richardson | – | – |
| FS | Nick Scott | Lathan Ransom | – | – |
| RCB | Jaycee Horn | Corey Thornton | – | – |
| NB | Chau Smith-Wade | – | – | – |
| PK | Ryan Fitzgerald | – | – | – |
| P | Sam Martin | – | – | – |
| H | Sam Martin | – | – | – |
| PR | Trevor Etienne | Hunter Renfrow | Jimmy Horn Jr. | – |
| KR | Trevor Etienne | Chuba Hubbard | Jimmy Horn Jr. | Rico Dowdle |
| LS | JJ Jansen | – | – | – |
San Francisco 49ers vs. Carolina Panthers Prediction
San Francisco is coming into the game as the favorites, and they should be able to handle the Panthers, as much of their core, including Brock Purdy, is back. This game goes to the Niners.
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