Two 1–0 squads collide at Lucas Oil Stadium as Daniel Jones’ Colts host Bo Nix and the Broncos. Books list Denver as a slight favorite, setting up a tight matchup in the AFC.
Colts vs Broncos Odds
The Broncos are 2.5-point favorites in the latest odds according to CBS Sports. ESPN’s matchup page lists the same spread and total, with FPI ever so slightly favoring the Colts.
Colts vs Broncos Best Bets
Broncos -2.5 seems like the best play in this matchup. Denver’s defense is intact at corner and humming up front. On the other side, the Indy cornerback room is thin with Charvarius Ward and Jaylon Jones both out.
Colts vs Broncos projected starting lineup for Week 2
Indianapolis Colts starting lineup
Offense
| Position | Player |
| QB | Daniel Jones |
| RB | Jonathan Taylor |
| WR | Michael Pittman Jr. |
| WR | Alec Pierce |
| WR | Josh Downs |
| TE | Tyler Warren |
| LT | Bernhard Raimann |
| LG | Quenton Nelson |
| C | Tanor Bortolini |
| RG | Matt Goncalves |
| RT | Braden Smith |
Defense
| Position | Player |
| LDE | Kwity Paye |
| LDT | Grover Stewart |
| RDT | DeForest Buckner |
| RDE | Laiatu Latu (Q) |
| WLB | Cameron McGrone |
| MLB | Zaire Franklin |
| SLB | Joe Bachie |
| LCB | Mekhi Blackmon |
| SS | Nick Cross |
| FS | Cam Bynum |
| RCB | Xavien Howard |
| NB | Kenny Moore II |
Specialists
| Position | Player |
| PK | Spencer Shrader |
| P/H | Rigoberto Sanchez |
| LS | Luke Rhodes |
| PR/KR | Anthony Gould |
Denver Broncos starting lineup
Offense
| Position | Player |
| QB | Bo Nix |
| RB | J.K. Dobbins |
| WR | Courtland Sutton |
| WR | Troy Franklin |
| WR | Marvin Mims Jr. |
| TE | Evan Engram |
| LT | Garett Bolles |
| LG | Ben Powers |
| C | Luke Wattenberg |
| RG | Quinn Meinerz |
| RT | Mike McGlinchey |
Defense
| Position | Player |
| LDE | Zach Allen |
| NT | D.J. Jones |
| RDE | John Franklin-Myers |
| WLB | Jonathon Cooper |
| LILB | Alex Singleton |
| RILB | Garret Wallow |
| SLB | Nik Bonitto |
| LCB | Pat Surtain II |
| SS | Talanoa Hufanga |
| FS | Brandon Jones |
| RCB | Riley Moss |
| NB | Ja’Quan McMillian |
Specialists
| Position | Player |
| PK | Wil Lutz |
| P/H | Jeremy Crawshaw |
| LS | Mitchell Fraboni |
| PR/KR | Marvin Mims Jr. |
Colts vs Broncos Depth Chart for Week 2
Indianapolis Colts Depth Chart
Offense
| Pos | 1st | 2nd |
| QB | Daniel Jones | Anthony Richardson |
| RB | Jonathan Taylor | DJ Giddens |
| WR | Michael Pittman Jr. | Adonai Mitchell |
| WR | Alec Pierce | Ashton Dulin |
| WR | Josh Downs | Anthony Gould |
| TE | Tyler Warren | Mo Alie-Cox |
| LT | Bernhard Raimann | Luke Tenuta |
| LG | Quenton Nelson | — |
| C | Tanor Bortolini | Danny Pinter |
| RG | Matt Goncalves | Dalton Tucker |
| RT | Braden Smith | Jalen Travis |
Defense
| Pos | 1st | 2nd |
| LDE | Kwity Paye | Tyquan Lewis |
| LDT | Grover Stewart | Eric Johnson II |
| RDT | DeForest Buckner | Neville Gallimore |
| RDE | Laiatu Latu (Q) | Samson Ebukam |
| WLB | Cameron McGrone | Jaylon Carlies (IR) |
| MLB | Zaire Franklin | Chad Muma |
| SLB | Joe Bachie | Segun Olubi |
| LCB | Mekhi Blackmon | — |
| SS | Nick Cross | Daniel Scott |
| FS | Cam Bynum | Rodney Thomas II |
| RCB | Xavien Howard | Johnathan Edwards |
| NB | Kenny Moore II | Chris Lammons |
Denver Broncos Depth Chart
Offense
| Pos | 1st | 2nd |
| QB | Bo Nix | Jarrett Stidham |
| RB | J.K. Dobbins | RJ Harvey |
| WR | Courtland Sutton | Pat Bryant |
| WR | Troy Franklin | Trent Sherfield Sr. |
| WR | Marvin Mims Jr. | — |
| TE | Evan Engram | Adam Trautman |
| LT | Garett Bolles | Matt Peart |
| LG | Ben Powers | Alex Palczewski |
| C | Luke Wattenberg | Alex Forsyth |
| RG | Quinn Meinerz | Nick Gargiulo (IR) |
| RT | Mike McGlinchey | Frank Crum |
Defense
| Pos | 1st | 2nd |
| LDE | Zach Allen | Jordan Jackson |
| NT | D.J. Jones | Malcolm Roach (IR) |
| RDE | John Franklin-Myers | Eyioma Uwazurike |
| WLB | Jonathon Cooper | Jonah Elliss |
| LILB | Alex Singleton | Justin Strnad |
| RILB | Garret Wallow | — |
| SLB | Nik Bonitto | Dondrea Tillman |
| LCB | Pat Surtain II | — |
| SS | Talanoa Hufanga | P.J. Locke |
| FS | Brandon Jones | Devon Key |
| RCB | Riley Moss | Kris Abrams-Draine |
| NB | Ja’Quan McMillian | Jahdae Barron |
How to watch Colts vs Broncos
The game will be on Sunday, Sept. 14, 2025, at 4:05 p.m. ET, in Lucas Oil Stadium. The broadcast will be on CBS and streaming from Paramount+ or NFL+.
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