Two major SEC powerhouses collide on the field as Diego Pavia and the No. 17 Vanderbilt Commodores take on the No. 10 LSU Tigers. There is a lot riding on this game, as both teams seek to go up the rankings as the race to the College Football Playoffs heats up.
With a lot on the line with this game, there have been a lot of talks from fans, some of whom predict that Vanderbilt quarterback Diego Pavia will never have an NFL career goodbye should they lose. Others were wondering how LSU was rated as the underdog for this matchup, which was happening at Vanderbilt’s home turf.
“Diego Pavia m*dg*t a** better soak all this in because he will never see an NFL roster,” said one fan.
Diego Pavia midget ass better soak all this in because he will never see an NFL roster
— Jameson Williams Fan Club (@goff_worshipper) October 18, 2025
“Let me just say this. If Brian Kelly cant figure out how to take this (extremely talented) #LSU roster and beat a Vanderbilt team giving him free bulletin board material, I’ll be officially out on him forever.” another fan added.
“An LSU Head Coach can’t lose to Vanderbilt in football. Just can’t happen.” another person added.
“A&M NEVER beats LSU at home. Never. I’m absolutely more worried about Vanderbilt than I am A&M.,” admitted one person.
“LSU hasn’t played great at all , I think Vanderbilt wins this game,” one person said.
“I literally can’t name one thing LSU does better than Vanderbilt,” one person pointed out.
The game has CFP implications, as both are ranked teams and are considered playoff contenders. The Commodores are currently leading the Tigers as of writing, with the team enjoying its best start in years so far.
What Do Oddsmakers Say About Vanderbilt vs. LSU?
As for the odds, the homefield Vanderbilt is considered the -2.5 favorites, according to DraftKings Sportsbook, with an over/under of 47.5 points. It is expected to be very close, however, as the Commodores have a -124 moneyline, with LSU’s moneyline is at +104.
Offensively, Vanderbilt has surprised everyone, being ranked seventh in the nation in points per game at 43,2, which shows that the team knows how to score and dismantle defenses. However, LSU has been red-hot as well, and quarterback Garrett Nussmeier has led them to a 5-1 record so far.
Related:
Alabama WR Ryan Williams Celebrates Forbes Feature With Powerful 6-Word Tribute to Mom
College Sports Network has you covered with the latest news, analysis, insights, and trending stories in college football, men’s college basketball, women’s college basketball, and college baseball!
