An important Big 12 matchup is taking place on Saturday night between the Colorado Buffaloes and TCU Horned Frogs. The Buffs are trying to get their season on track after falling to 2-3 with a 24-21 loss to No. 23-ranked BYU last week. TCU is looking to get back on the right track after losing 24-27 to No. 25-ranked Arizona State last week. Both teams are still looking for their first conference wins of the year.
Colorado vs. TCU Odds
TCU is a -520 favorite to win this game and Colorado is a +400 underdog, according to FanDuel.
Colorado vs. TCU Best Bets
We think the best bet for this matchup is the Colorado moneyline (+400). While TCU should be favored, we think the line does not give enough credit to the Buffaloes. Both teams are coming off narrow losses to ranked opponents. As a result, we expect to see a competitive matchup.
Colorado vs TCU injury report. #SkoBuffs pic.twitter.com/zBa9WvWcd3
— GUCCE🦬🐦⬛ (@gucceCU) October 2, 2025
Colorado vs. TCU Starting Lineup For Week 6
Colorado Starting Lineup
| WR-X | Joseph Williams |
| WR-Z | Sincere Brown |
| WR-SL | Dre’lon Miller |
| LT | Jordan Seaton |
| LG | Xavier Hill |
| C | Zarian McGill |
| RG | Zylon Crisler |
| RT | Larry Johnson III |
| TE | Zach Atkins |
| QB | Kaidon Salter |
| RB | Micah Welch |
| LDE | Keaten Wade |
| NT | Anquin Barnes Jr. |
| DT | Brandon Davis-Swain |
| RDE | Arden Walker |
| WLB | Jeremiah Brown |
| MLB | Martavius French |
| LCB | RJ Johnson |
| SS | Ben Finneseth |
| FS | Carter Stoutmire |
| RCB | DJ McKinney |
| NB | Preston Hodge |
| P | Damon Greaves |
| K | Alejandro Mata |
TCU Starting Lineup
| WR-X | Jordan Dwyer |
| WR-Z | Eric McAlister |
| WR-SL | Joseph Manjack IV |
| LT | Ryan Hughes |
| LG | Cade Bennett |
| C | Coltin Deery |
| RG | Carson Bruno |
| RT | Ben Taylor-Whitfield |
| TE | DJ Rogers |
| QB | Josh Hoover |
| RB | Jeremy Payne |
| LDE | Paul Oyewale |
| NT | Markis Deal |
| DT | Ansel Din-Mbuh |
| RDE | Devean Deal |
| WLB | Kaleb Elarms-Orr |
| MLB | Namdi Obiazor |
| LCB | Channing Canada |
| SS | Jamel Johnson |
| FS | Bud Clark |
| RCB | Vernon Glover |
| NB | Austin Jordan |
| P | Ethan Craw |
| K | Kyle Kemmermann |
Colorado vs. TCU Depth Chart For Week 6
Colorado Depth Chart
| WR-X | Hykeem Williams | ||
| WR-Z | Terrell Timmons Jr. | Jack Hestera | |
| WR-SL | Quentin Gibson | Isaiah Hardge | Kaleb Mathis |
| LT | Andre Roye Jr. | ||
| LG | Tyler Brown | ||
| C | Cooper Lovelace | ||
| RG | Yahya Attia | ||
| RT | Kareem Harden | ||
| TE | Sav’ell Smalls | Brady Kopetz | |
| QB | Ryan Staub | Julian Lewis | |
| RB | DeKalon Taylor | Simeon Price | |
| LDE | London Merritt | ||
| NT | Tavian Coleman | Jehiem Oatis | Taurean Carter II |
| DT | Amari McNeill | Tawfiq Thomas | |
| RDE | Quency Wiggins | Alexander McPherson | |
| WLB | Reginald Hughes | ||
| MLB | Shaun Myers | ||
| LCB | Teon Parks | Makari Vickers | |
| SS | Tawfiq Byard | ||
| FS | John Slaughter | ||
| RCB | Ivan Yates | ||
| NB | Tyrecus Davis | ||
| P | Daniel Gerlach | ||
| K | Buck Buchanan |
TCU Depth Chart
| WR-X | Terry Shelton | ||
| WR-Z | Dozie Ezukanma | Jacobe Hayes | |
| WR-SL | Ed Small | Jordyn Bailey | |
| LT | Quinton Harris | ||
| LG | Rasheed Jackson | ||
| C | Cooper Powers | ||
| RG | Remington Strickland | ||
| RT | Witten Van Hoy | ||
| TE | Chase Curtis | Lafayette Kaiuway | |
| QB | Ken Seals | Adam Schobel | |
| RB | Trent Battle | Nate Palmer | Jon Denman |
| LDE | Zach Chapman | Chad Woodfork | |
| NT | Connor Lingren | Sterlin Brooks | Floyd Guidry |
| DT | Tristan Johnson | Perry Cole Jr. | |
| RDE | Jonathan Bax | Travis Jackson | |
| WLB | Michael Teason | Hudson Hooper | |
| MLB | Max Carroll | ||
| LCB | Avery Helm | ||
| SS | Kaden McFadden | Ryan Yaites | |
| FS | Jordan Lester | ||
| RCB | Jevon McIver Jr. | Gil Jackson | |
| NB | Kylin Jackson | ||
| P | Easton Black | ||
| K | Nate McCashland |
How To Watch Colorado vs. TCU
Colorado vs. TCU will be broadcast on FOX starting at 7:30 p.m. ET on Saturday.
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