The 2025 season has college football fans buzzing with excitement, and the league championship battle is expected to be among the fiercest yet. According to the latest betting odds from FanDuel Sportsbook, a few familiar powerhouses and some rising programs are leading the charge to capture conference titles in the ACC, SEC, Big Ten, and Big 12. Let’s look at who’s favored and why they’re in a strong position to win.
2025 Conference Title Favorites: Who Leads the Odds in the ACC, SEC, Big Ten, and Big 12?
ACC: Clemson Tigers (+165)
It’s not much of a surprise that Clemson is again at the top of the ACC odds. The Tigers are still the best in the conference despite having a few “down” years by their high standards. With quarterback Cade Klubnik taking on a more significant leadership role and head coach Dabo Swinney having built a consistent winner, Clemson’s offense appears ready for a breakout year.
The Tigers’ defense is stacked with future NFL talent, especially in the trenches. If Clemson can find more offensively dynamic plays, it’ll be tough to unseat them in the ACC.
Big 12: Texas Tech Red Raiders (+550)
It might surprise some casual fans that Texas Tech has quietly developed a contender under Joey McGuire. The Red Raiders finished the 2024 season strong, and they’re ready to contend for the Big 12 title with a returning quarterback and much-improved defense. Although they still have a fast-paced and aggressive offense, oddsmakers are paying attention to their defensive upgrades.
In a wide-open Big 12 where traditional powers like Oklahoma and Texas have moved to the SEC, Texas Tech is as likely as anyone to win a spot in the SEC.
Big Ten: Ohio State Buckeyes (+200)
Ohio State is still one of the best teams in the Big Ten. Even when the Buckeyes don’t win a national championship, they are constantly at the heart of the conference. Their 2025 roster is loaded again, with arguably the best group of wide receivers in the country and a retooled defense that showed flashes of dominance last season.
The quarterback position will be critical, but Ohio State has options and a history of producing talented quarterbacks. With Michigan in a transition year and Penn State still trying to get over the hump, the Buckeyes are clear favorites.
SEC: Texas Longhorns (+260)
Texas is a new member of the SEC, and they are quickly establishing themselves as a formidable force. The Longhorns have one of the best lineups going into their first full SEC season after a successful 2024 season. Even though Quinn Ewers is leaving for the NFL, the Longhorns have one of the top offensive lines in the nation and a thriving quarterback pipeline.
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Texas is near the top of the SEC odds board, which is understandable given that their defense has been improving over time and their coaching staff knows how to win big games. Although the journey won’t be simple, the Longhorns appear prepared.
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