College Football Picks, Predictions for Week 11 Include Fading Clemson and Backing Arizona

After a modest Week 10, college football's Week 11 slate offers plenty of profit opportunities. Let's make some picks and predictions for Saturday.

We went 0.500 in Week 10 with some intriguing plays and frustrating losses. With Week 11, we have another chance to get into the positive before the bowl schedule begins.

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Week 11 College Football Picks and Predictions

Last Week: 4-4-0 (0.500)
This Season: 38-41-0 (0.481)
Overall Record: 119-124-3 (0.490)

For all current betting odds surrounding the college football season, check out our live betting odds and make your plays today!

All lines are via Draft Kings Sportsbook. You can find the best available odds from sportsbooks all over the country below as well.

Arizona -9.5 (-110) vs. Colorado +9.5 (-110)

Hats off to Arizona Wildcats head coach Jedd Fisch.

He inherited a program that won just a single game between 2020 and 2021 and is now bowl-eligible after winning three consecutive games against ranked opponents. They have a chance to win their seventh game at Folsom Field and it’s very winnable.

Noah Fifita has stepped in for Jayden de Laura very well and is elevating Tetairoa McMillan and Jacob Cowing. Pair that with a group of running backs that have been excellent and you have a recipe for success.

The Colorado Buffaloes have struggled as of late and they can be narrowed down to offensive execution — more specifically, the offensive line.

Head coach Deion Sanders even said during a press conference that they would likely have a new one next season. He then paired that quote with demoting offensive coordinator Sean Lewis from play-caller. Things aren’t going well for the Buffaloes but it’s par for the course for a team that has over-achieved this season.

This line has moved significantly. It opened at Arizona -6 and has risen as of this writing — Draft Kings Sportsbook has moved it up to -10.5. On Sunday, I grabbed this at -9.5, and I’d consider playing it up to -11.5. The Wildcats are much stronger in the trenches on both sides of the ball and have better weapons on the outside.

Bet: Arizona -9.5 (-110)

UConn +26.5 (-110) vs. James Madison -26.5 (-110)

We are going to keep this one simple.

The UConn Huskies were handled by Tennessee last week 59-3 and James Madison has a better offense both on the ground and through the air. They should easily be able to clear 26.5 points, especially considering they have covered six of their last seven games.

The Dukes are going to extend their record to 10-0 and continue putting pressure on the NCAA to grant them postseason eligibility. I’m so confident in this bet that I’m putting three units on it.

Bet: James Madison -26.5 (-110)

Michigan -4.5 (-110) vs. Penn State +4.5 (-110)

This looks like it could be the game of the day.

The Michigan Wolverines might be marred by the Connor Stallions scandal, but they are ready for their first major test. There is a slight chance that the Big 10 will suspend head coach Jim Harbaugh for this game, but that news would have to drop on Friday morning for it to happen.

What the Wolverines do have is a balanced team that has taken a step forward on offense with J.J. McCarthy and Roman Wilson. Their connections have added a dynamic element to the Wolverines’ offense and provided a great complement to the rushing attack. They have scored at least 41 points in each of the last five games.

The Penn State Nittany Lions couldn’t quite find a win against Ohio State three weeks ago. The passing offense couldn’t get anything going down the field and that raises more questions.

Is it because Drew Allar can’t attack down the field, James Franklin doesn’t trust him to do so, or a little bit of both?

They let him air the ball out a bit against Indiana but the Wolverines will have the best defense the Nittany Lions will see all season. After a slow start and just a nine-point win, there are questions surrounding Franklin and if the program can ever get over the hump.

Penn State hasn’t been able to exceed expectations, and they won’t get there on Saturday. Michigan wins and sets up a potential undefeated matchup against the Buckeyes.

Bet: Michigan -4.5 (-110)

Texas Tech +3.5 (-110) vs. Kansas -3.5 (-110)

The Texas Tech Red Raiders haven’t had the season they envisioned. With some predicting that the Red Raiders could potentially win the Big 12, they sputtered out of the gate, losing to Wyoming and Oregon.

With Tyler Shough out, Behren Morton has acclimated well and is the best quarterback in the room. The offense hasn’t been consistent, but they looked significantly better against the TCU Horned Frogs last week.

What they are running into is a really good Kansas team that is 7-2 on the season with their only losses being to Texas and Oklahoma State.

They aren’t just a team that beats on lesser opponents either. The Kansas Jayhawks beat Oklahoma at home two weeks ago and survived a tough Iowa State team last Saturday.

This game is going to come down to quarterback Jason Bean, or maybe even Jalon Daniels pending his back injury, attacking a defense that struggles against the pass. The misdirection that the Jayhawks run consistently is going to give the Red Raiders issues.

The Jayhawks will enjoy home-field advantage and get one step closer to potentially making the Big 12 Championship Game.

Bet: Kansas -3.5 (-110)

Other Bets

Stanford +20 (-110) @ Oregon State

Oklahoma State -2.5 (-110) @ UCF

Georgia Tech +15.5 (-110) @ Clemson

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