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    Georgia Tech vs. Louisville Prediction: Spread, DFS Picks, and More

    Can the Yellow Jackets remain perfect against AP-ranked ACC opponents under Brent Key? We've got the latest odds and a Georgia Tech vs. Louisville prediction.

    The No. 19 Louisville Cardinals will look to keep their unblemished record alive as they begin conference play at home against the Georgia Tech Yellow Jackets who are 5-0 against AP-ranked ACC opponents under head coach Brent Key.

    The Yellow Jackets have already played two conference games, defeating then-No. 10 Florida State in the Aer Lingus College Football Classic to open the season before falling to unranked Syracuse on the road two weeks later.

    This is a classic strength vs. strength matchup in the trenches as Saturday will pit Georgia Tech’s offensive line (zero sacks allowed) up against Louisville’s pass rush (nine sacks through two games).

    Georgia Tech vs. Louisville Betting and DFS Preview

    All Georgia Tech vs. Louisville odds are from DraftKings Sportsbook and are correct as of Tuesday, Sept. 17.

    • Spread
      Louisville -10.5
    • Moneyline
      Georgia Tech +310, Louisville -395
    • Over/Under
      57.5
    • Game Time
      3:30 p.m. ET
    • Location
      L&N Federal Credit Union Stadium | Louisville, Ky.
    • Predicted Weather at Kick
      93 degrees, partly cloudy and hot
    • How To Watch
      ESPN2, ESPN+

    After failing to cover the spread in four of its final five games of 2023, Louisville has reversed that trend by starting 2024 with two straight covers, both as significant favorites, against the FCS’s Austin Peay and CUSA’s Jacksonville State.

    The Cardinals went 2-2 ATS as a double-digit favorites last season, including a 1-1 ATS mark against conference opponents.

    MORE: CFN Betting Parlay Calculator

    Georgia Tech has covered the number in three of its four games to open the 2024 season. The Yellow Jackets are 7-3 ATS in their last 10 ACC games dating back to the start of last season.

    The total at 58.5 is interesting considering how dominant the Louisville offense has been through its opening two games. Georgia Tech will be the best defense the Cardinals have seen by far, though it’s worth noting Louisville has averaged 55.5 points this season (third in FBS) and scored fewer than 30 points at home just once under Jeff Brohm.

    Top DFS Picks and Fantasy Plays

    • QB Haynes King (GT)
    • QB Tyler Shough (LOU)
    • RB Jamal Haynes (GT)
    • RB Maurice Turner (LOU)
    • WR Malik Rutherford (GT)
    • WR Chase Lane (GT)
    • WR Eric Singleton Jr. (GT)
    • WR Chris Bell (LOU)
    • WR Ja’Corey Brooks (LOU)
    • WR Jadon Thompson (LOU)
    • TE Avery Boyd (GT)
    • TE Jackson Hawes (GT)
    • TE Mark Redman (LOU)

    The quarterback matchup between Georgia Tech’s Haynes King and Louisville’s Tyler Shough should be one for the ages.

    King leads the conference in completions (81) and completion percentage (76.4%) while Shough has the most touchdown passes (six) without an interception in the ACC. Both have averaged over nine yards per attempt at this point of the season, both on pace to establish career highs in that category.

    Both King and Shough spread the joy around too — four different Louisville pass catchers have found the endzone this season while that number is five on the Georgia Tech side.

    Prediction for Georgia Tech vs. Louisville

    There is a lot to like about this Louisville team, though they haven’t received a ton of national attention and won’t until they defeat an opponent from a power conference. Here is their chance with a quality, well-coached Georgia Tech team coming to town.

    The Cardinals haven’t lost an August/September game under head coach Jeff Brohm after they won their first six contests last season.

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    Running the ball is an important part of the Cardinals’ offense, and it sets up Shough to utilize play action in the passing game. Louisville has averaged 8.2 yards per carry to rank second in the country behind only Boise State (8.7).

    Again, Georgia Tech is different and won’t be an easy task, but the Cardinals are rolling, coming off a bye and are still enjoying home cookin’.

    Prediction: Louisville 39, Georgia Tech 21

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