The Tampa Bay Buccaneers and San Francisco will compete on Sunday at 4:25 p.m. ET. It should be a good game between two of the top teams in the league. Here is everything you need to know about the matchup.
Tampa Bay Buccaneers Injury Report
Mike Evans
WR Mike Evans is out with a hamstring injury.
Chris Godwin Jr.
WR Chris Godwin Jr. is out with a fibula injury.
Bucky Irving
RB Bucky Iriving is out with foot and shoulder injuries.
Zyon McCollum
CB Zyon McCollum is out with a thumb injury.
Benjamin Morrison
CB Benjamin Morrison is out with a hamstring injury.
Josh Williams
RB Josh Williams is out with a concussion.
Christian Izien
DB Christian Izien is questionable with a quad injury.
Our Week 6 game statuses 👇 pic.twitter.com/2QiyIc7ol8
— Tampa Bay Buccaneers (@Buccaneers) October 10, 2025
San Francisco 49ers Injury Report
Yetur Gross-Matos
DL Yetur Gross-Matos is out with knee and hamstring injuries.
Ricky Pearsall
WR Ricky Pearsall is out with a knee injury.
Brock Purdy
QB Brock Purdy is out with a toe injury.
Jordan Watkins
WR Jordan Watkins is out with a calf injury.
Kevin Givens
DL Kevin Givens is out with a hand injury.
George Kittle
TE George Kittle remains out after suffering a hamstring injury in Week 1.
Alfred Collins
DL Alfred Collins is questionable with a knee injury.
Kalia Davis
DL Kalia Davis is questionable with a hand injury.
Upton Stout
CB Upton Stout is questionable with an ankle injury.
Malik Mustapha
S Malik Mustapha is questionable with a knee injury.
Tampa Bay Buccaneers Depth Chart
| LWR | Sterling Shepard | Kameron Johnson | |
| RWR | Emeka Egbuka | Ryan Miller | |
| SWR | Tez Johnson | ||
| LT | Tristan Wirfs | ||
| LG | Ben Bredeson | Dan Feeney | |
| C | Graham Barton | ||
| RG | Elijah Klein | Luke Haggard | |
| RT | Charlie Heck | Benjamin Chukwuma | |
| TE | Cade Otton | Payne Durham | Devin Culp |
| QB | Baker Mayfield | Teddy Bridgewater | |
| RB | Rachaad White | Sean Tucker | Owen Wright |
| LDE | Logan Hall | C.J. Brewer | |
| NT | Vita Vea | Elijah Simmons | |
| RDE | Greg Gaines | Elijah Roberts | |
| LOLB | Haason Reddick | Anthony Nelson | |
| LILB | Lavonte David | Deion Jones | |
| RILB | SirVocea Dennis | John Bullock | |
| ROLB | Yaya Diaby | Chris Braswell | Markees Watts |
| LCB | Kindle Vildor | Josh Hayes | |
| SS | Tykee Smith | Kaevon Merriweather | |
| FS | Antoine Winfield Jr. | Sebastian Castro | |
| RCB | Jamel Dean | ||
| NB | Jacob Parrish | ||
| P | Riley Dixon | ||
| K | Chase McLaughlin |
San Francisco 49ers Depth Chart
| LWR | Kendrick Bourne | Skyy Moore | ||
| RWR | Demarcus Robinson | |||
| SWR | Jauan Jennings | Marquez Valdes-Scantling | ||
| LT | Trent Williams | |||
| LG | Connor Colby | |||
| C | Jake Brendel | Matt Hennessy | ||
| RG | Dominick Puni | Drew Moss | ||
| RT | Colton McKivitz | Austen Pleasants | ||
| TE | Jake Tonges | Luke Farrell | Brayden Willis | |
| QB | Mac Jones | Adrian Martinez | ||
| RB | Christian McCaffrey | Brian Robinson Jr. | Isaac Guerendo | Jordan James |
| FB | Kyle Juszczyk | |||
| LDE | Bryce Huff | Trevis Gipson | ||
| LDT | Jordan Elliott | C.J. West | ||
| RDE | Mykel Williams | Sam Okuayinonu | ||
| WLB | Dee Winters | Tatum Bethune | Curtis Robinson | |
| MLB | Fred Warner | Luke Gifford | Nick Martin | |
| LCB | Renardo Green | Darrell Luter Jr. | ||
| SS | Marques Sigle | Ji’Ayir Brown | ||
| FS | Jason Pinnock | Malik Mustapha | ||
| RCB | Deommodore Lenoir | Chase Lucas | ||
| NB | Siran Neal | |||
| P | Thomas Morstead | |||
| K | Eddy Pineiro |
How to Watch Tampa Bay Buccaneers vs San Francisco 49ers
This game will be broadcast on CBS. Alternatively, it will be available to stream on Paramount+.
Tampa Bay Buccaneers vs San Francisco 49ers Prediction
These are two strong teams that are off to 4-1 starts. However, we favor the Bucs in this matchup. They have the advantage of playing at home, and they are not as injured as the 49ers. QB Baker Mayfield has proven that he can show up in close games, and we think he will thrive in that situation again on Sunday.
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