The Indianapolis Colts have been the biggest positive surprise this season, winning their first four games. On Sunday, they will host the Arizona Cardinals, who have started the season 2-3. Here is everything you need to know about the matchup.
Indianapolis Colts Injury Report
Tyler Goodson
RB Tyler Goodson has a groin injury and will not play.
Kenny Moore II
CB Kenny Moore II is out with an achilles injury for the third straight game.
Arizona Cardinals Injury Report
Darius Robinson
DL Darius Robinson is out with a pectoral injury.
Kyler Murray
QB Kyler Murray is questionable with a foot injury.
The Cardinals will either be starting Jacoby Brissett or Kyler Murray on a bad foot vs. the Colts. pic.twitter.com/CAElPVJ52m
— LastMenStanding (@LastMenPod) October 9, 2025
Blake Gillikin
P Blake Gillikin is questionable with a back injury.
Max Melton
CB Max Melton is questionable with a hamstring injury.
Zay Jones
WR Zay Jones is questionable with a knee injury.
Cody Simon
LB Cody Simon is questionable with a knee injury.
Mack Wilson Sr.
LB Mack Wilson Sr. is questionable with an ankle injury.
Indianapolis Colts Depth Chart
| QB | Daniel Jones | Anthony Richardson Sr. | Riley Leonard | |
| RB | Jonathan Taylor | Tyler Goodson | DJ Giddens | |
| WR-L | Michael Pittman Jr. | Ashton Dulin | ||
| WR-R | Alec Pierce | Adonai Mitchell | ||
| WR-S | Josh Downs | Anthony Gould | ||
| LT | Bernhard Raimann | Jalen Travis | ||
| LG | Quenton Nelson | |||
| C | Tanor Bortolini | Danny Pinter | ||
| RG | Matt Goncalves | Dalton Tucker | ||
| RT | Braden Smith | Luke Tenuta | ||
| TE | Tyler Warren | Mo Alie-Cox | Drew Ogletree | Will Mallory |
| LDE | Kwity Paye | Tyquan Lewis | JT Tuimoloau | |
| NT | Grover Stewart | Neville Gallimore | Eric Johnson II | |
| RDE | Laiatu Latu | Samson Ebukam | ||
| WLB | Germaine Pratt | Austin Ajiake | Segun Olubi | |
| MLB | Zaire Franklin | Chad Muma | Buddy Johnson | |
| LCB | Charvarius Ward | Johnathan Edwards | ||
| RCB | Mekhi Blackmon | |||
| SS | Nick Cross | Trey Washington | ||
| FS | Cam Bynum | Rodney Thomas II | ||
| NB | Kenny Moore II | Chris Lammons | ||
| P | Rigoberto Sanchez | |||
| K | Michael Badgley |
Arizona Cardinals Depth Chart
| QB | Kyler Murray | Jacoby Brissett | |
| RB | Michael Carter | Emari Demercado | Bam Knight |
| WR-L | Marvin Harrison Jr. | Simi Fehoko | |
| WR-R | Zay Jones | Xavier Weaver | |
| WR-S | Michael Wilson | Greg Dortch | |
| LT | Paris Johnson Jr. | Kelvin Beachum | |
| LG | Isaiah Adams | Will Hernandez | |
| C | Hjalte Froholdt | ||
| RG | Evan Brown | Jon Gaines II | |
| RT | Jonah Williams | Josh Fryar | Demontrey Jacobs |
| TE | Trey McBride | Elijah Higgins | Travis Vokolek |
| LDE | Calais Campbell | Bilal Nichols | |
| NT | Dalvin Tomlinson | PJ Mustipher | |
| RDE | Darius Robinson | Dante Stills | |
| LOLB | Baron Browning | Zaven Collins | |
| MLB | Akeem Davis-Gaither | Owen Pappoe | |
| ROLB | Josh Sweat | Jordan Burch | Xavier Thomas |
| WLB | Mack Wilson Sr. | Cody Simon | |
| LCB | Will Johnson | Kei’Trel Clark | Elijah Jones |
| RCB | Max Melton | Denzel Burke | |
| SS | Budda Baker | Kitan Crawford | |
| FS | Dadrion Taylor-Demerson | Darren Hall | |
| NB | Jalen Thompson | ||
| P | Blake Gillikin | Pat O’Donnell | |
| K | Chad Ryland |
How to Watch Indianapolis Colts vs Arizona Cardinals
This game between Indianapolis and Arizona will be broadcast on Fox. It can also be streamed on NFL+, Prime Video, YouTube TV, and Paramount+.
Indianapolis Colts vs Arizona Cardinals Prediction
We are predicting the Colts to win this matchup. They have been the far better team this season, and if Kyler Murray is not available for Arizona, it could even be a blowout.
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