The Houston Texans suffered a major setback when starting running back Joe Mixon went down with an injury in the preseason. For fantasy football managers, Mixon’s absence is a brutal blow, especially given his strong usage last year in Houston’s offense alongside C.J. Stroud.
While his timetable is still unclear, managers must pivot quickly to find reliable replacements. Here are five running backs who could step in and provide immediate fantasy value.
Trey Benson, Arizona Cardinals
With James Conner landing on injured reserve because of a foot injury, Benson is the next man up in Arizona. The rookie has already shown burst in limited action, and the Cardinals’ offense leans heavily on the ground game. His upside makes him one of the top waiver-wire adds this week.
Rico Dowdle, Carolina Panthers
Dowdle could be pushed into a starting role if Chuba Hubbard’s calf issue sidelines him. Carolina has struggled offensively, but starting volume is king in fantasy, and Dowdle has shown he can be effective when given carries. He’s a sneaky option for those in deeper leagues.
Hassan Haskins, Los Angeles Chargers
The Chargers’ backfield is banged up, with Najee Harris questionable due to a leg injury. Haskins is in line for increased work, especially on early downs. In an offense that still looks to stay balanced, Haskins has the chance to deliver FLEX-worthy numbers if Harris sits.
Kenneth Gainwell, Pittsburgh Steelers
The Steelers are another team dealing with injury questions, as Jaylen Warren’s status remains uncertain. If Warren can’t go for a few weeks, expect Gainwell to step up. Warren has played well the last few weeks, so Gainwell taking over the volume could be a great pick up.
Emari Demercado, Arizona Cardinals
With Conner out, Demercado is another name to monitor in Arizona. While Benson may lead the way, Demercado has the experience and could carve out work in passing situations, making him a viable PPR option.
Final Thoughts
Joe Mixon’s injury leaves fantasy managers scrambling, but there are options across the league that can fill the void. From rookies like Trey Benson to veterans like Kenneth Gainwell, staying active on the waiver wire is the key to surviving Mixon’s absence.
Read More:
Best Running Backs for Fantasy Football 2025: Week 5 Start ‘Em, Sit ‘Em Guide Ft. Breece Hall
College Sports Network has you covered with the latest news, analysis, insights, and trending stories in football, basketball, and more!
