The Syracuse vs. Duke game is an impactful one on Saturday for the ACC standings. The Orange and Blue Devils will battle it out to improve their spot in their conference. The game is scheduled to kick off at Noon ET on Saturday. Here is everything you need to know about the matchup.
Syracuse vs. Duke Odds
Duke is the betting favorite, according to FanDuel, at -188. Syracuse is a +155 underdog.
Syracuse vs. Duke Best Bets
While Duke is the betting favorite, we think the best bet is the Syracuse moneyline. The Orange have won three games this year and look like a strong team. +155 is good value to bet on the Orange.
Initial injury report ahead of Duke football vs. Syracuse: pic.twitter.com/VtC1DesACN
— Anna Snyder (@annaesnydr) September 26, 2025
Syracuse vs. Duke Projected Starting Lineup For Week 5
Syracuse Starting Lineup
| WR-X | Justus Ross-Simmons |
| WR-Z | Darrell Gill Jr. |
| WR-SL | Johntay Cook |
| LT | Trevion Mack |
| LG | TJ Ferguson |
| C | Austin Collins |
| RG | Joe Cruz |
| RT | Da’Metrius Weatherspoon |
| TE | Dan Villari |
| QB | Steve Angeli |
| RB | Yasin Willis |
| DE | Denis Jaquez Jr. |
| NT | Dion Wilson Jr. |
| DT | George Rooks |
| JACK | David Reese |
| WLB | Antoine Deslauriers |
| MLB | Gary Bryant III |
| LCB | Demetres Samuel Jr. |
| SS | Duce Chestnut |
| FS | Devin Grant |
| RCB | Chris Peal |
| NB | Berry Buxton III |
| P | Jack Stonehouse |
| K | Tripp Woody |
Duke Starting Lineup
| WR-X | Sahmir Hagans |
| WR-Z | Cooper Barkate |
| WR-Y | Que’Sean Brown |
| LT | Bruno Fina |
| LG | Jordan Larsen |
| C | Matt Craycraft |
| RG | Justin Pickett |
| RT | Brian Parker II |
| TE | Jeremiah Hasley |
| QB | Darian Mensah |
| RB | Jaquez Moore |
| DE | Wesley Williams |
| NT | Aaron Hall |
| DT | Josiah Green |
| VYPER | Vincent Anthony Jr. |
| WLB | Tre Freeman |
| MLB | Nick Morris Jr. |
| STAR | Jaiden Francois |
| LCB | Kimari Robinson |
| SS | DaShawn Stone |
| FS | Caleb Weaver |
| RCB | Chandler Rivers |
| P | Kade Reynoldson |
| K | Todd Pelino |
Syracuse vs. Duke Depth Chart for Week 5
Syracuse Depth Chart
| WR-X | Umari Hatcher | |
| WR-Z | Jaylan Hornsby | |
| WR-SL | Tyshawn Russell | |
| LT | Naquil Betrand | |
| LG | Byron Washington | |
| C | Joshua Miller | |
| RG | Zach Rice | |
| RT | Kam Pringle | |
| TE | David Clement | Jamie Tremble |
| QB | Rickie Collins | |
| RB | Will Nixon | |
| DE | Kevin Jobity Jr. | |
| NT | Rashard Perry | Elijah Fuentes-Cundiff |
| DT | Isaiah Hastings | Chris Thomas |
| JACK | David Omopariola | |
| WLB | Derek McDonald | |
| MLB | Anwar Sparrow | James Heard |
| LCB | Greg Delaine | Kaylib Singleton |
| SS | Braheem Long Jr. | |
| FS | Cornell Perry | |
| RCB | Davien Kerr | |
| NB | Ibn McDaniels | |
| P | Mateja Pavlovich | |
| K | Jadyn Oh |
Duke Depth Chart
| WR-X | Andrel Anthony | Jaivon Solomon | |
| WR-Z | Chase Tyler | Kavon Simmons | |
| WR-Y | Jayden Moore | Jamien Little | |
| LT | Caleb Dorris | Roman Fina | |
| LG | Reagan McCranie | Daniel Boyd | |
| C | Bradley Smith | Ryan Daly | |
| RG | Gemyel Allen | Jamin Brown | |
| RT | Jack Small | Cole Allen | |
| TE | Jake Taylor | Landen King | |
| QB | Henry Belin IV | Dan Mahan | |
| RB | Anderson Castle | Peyton Jones | Nate Sheppard |
| DE | Tyshon Reed | Bryce Davis | |
| NT | David Anderson | Desmond Aladuge | |
| DT | Preston Watson | Terry Simmons Jr. | |
| VYPER | Kevin O’Connor | Kobe Smith | |
| WLB | Kendall Johnson | Bradley Gompers | |
| MLB | Luke Mergott | Elliott Schaper | |
| STAR | Dawson Andrew | Will Felder Jr. | |
| LCB | Moussa Kane | Kyren Condoll | |
| SS | Ma’khi Jones | Leon Griffin III | |
| FS | Andrew Pellicciotta | George Wright | |
| RCB | Landan Callahan | Kaleb Lanier | |
| P | Ryan Degyansky | ||
| K | Cosme Salas |
How To Watch Syracuse vs. Duke
Syracuse vs. Duke will be broadcast on the ACC Network. It will also be streamed on Fubo and the ESPN app.
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