Week 4 of the 2025 college football season is approaching, and Syracuse vs Clemson is a highly anticipated matchup. After a Week 1 loss to No. 15-ranked Tennessee, the Orange have bounced back, winning their past two games. Conversely, while the Tigers were one of the preseason favorites to win the ACC, they have lost two of their first three games, both to ranked opponents. They also looked unimpressive in their win over Troy in Week 2.
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— The Greenville News (@GreenvilleNews) September 15, 2025
Here is everything you need to know about the upcoming matchup.
Syracuse vs Clemson: Key Players to Watch
Quarterback play could play a big role in this game. Steve Angeli transferred to the Orange from the Notre Dame Fighting Irish during the offseason and has performed well in his first three games. He has thrown for 380+ yards in each of his past two games. Now he will be tested against an opponent that at the start of the season was projected to be a contender.
For Clemson, QB Cade Klubnik was a preseason favorite for the Heisman Trophy. However, he has struggled in his first three games, only throwing three TD passes while also throwing three interceptions. If the Tigers are going to turn their season around, they will need Klubnik to get back to the form he showed last year.
Odds and Betting Lines for Syracuse vs Clemson
Odds via FanDuel.
- Moneyline: Syracuse (+570), Clemson (-850)
- Spread: Syracuse +17.5 points (-110), Clemson -17.5 points (-110)
- Total: Over 55.5 points (-105), Under 55.5 points (-115)
Syracuse vs Clemson Predictions
Syracuse vs Clemson is not expected to be one of the most competitive matchups of the day. While the Clemson Tigers have struggled early in the season, they are heavily favored to come out on top against the Syracuse Orange. The spread is the biggest indicator of this prediction as Clemson is favored to win by 17.5 points.
We will not be making a bold prediction here. We predict Clemson to take a step towards getting their season on track by winning over Syracuse. However, if you are interested in betting, you should consider betting the spread. With the Tigers looking shaky to start their season, there is a solid chance the Orange will be able to make the game more competitive than the spread indicates, even if they lose.
Best Bet: Syracuse +17.5 points (-110).
Read More:
- Top 10 Comical Cade Klubnik-Dabo Swinney Jokes Cracking Up the Internet As Clemson Struggles Against Georgia Tech in Week 3
- “Needs To Stop Thinking He’s Michael Vick”: Fans Call Out Cade Klubnik as Clemson QB’s Turnover Puts Dabo Swinney’s Squad On Backfoot vs Georgia Tech
- ‘LFG NUSS’ ‘Congrats!!’: Steve Angeli, Drew Pyne and More CFB Stars Left Ecstatic Over LSU QB Garrett Nussmeier’s Engagement Snaps
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