The repeat of the Super Bowl matchup is on tap in Week 2 as Kansas City hosts Philadelphia. The market is leaning towards the Eagles while both teams will be missing an offensive starter. The Chiefs look to bounce back after losing their opener to the Chargers in Brazil and the Eagles are coming off a home win against the Cowboys.
Chiefs vs Eagles Odds
Books list Eagles -1.5 with a total between 47–48 ahead of kickoff according to Fox Sports.
Chiefs vs Eagles Best Bets
The Eagles -1.5 seems like the best bet on the board. Kansas City is without rookie burner Xavier Worthy (shoulder) and still missing Rasheed Rice due to suspension. Patrick Mahomes is without options and it showed in the loss to the Los Angeles Chargers. The Eagles offense looked decent against the Cowboys and even in Arrowhead they should have enough to get through with the win.
Chiefs vs Eagles Projected Starting Lineup For Week 2
Kansas City Chiefs Starting Lineup
Offense
| Position | Player |
| QB | Patrick Mahomes |
| RB | Isiah Pacheco |
| WR | JuJu Smith-Schuster |
| WR | Hollywood Brown |
| WR | JuJu Smith-Schuster |
| TE | Travis Kelce |
| LT | Josh Simmons |
| LG | Kingsley Suamataia |
| C | Creed Humphrey |
| RG | Trey Smith |
| RT | Jawaan Taylor |
Defense
| Position | Player |
| LDE | George Karlaftis |
| LDT | Chris Jones |
| RDT | Omarr Norman-Lott |
| RDE | Mike Danna |
| WLB | Drue Tranquill |
| MLB | Nick Bolton |
| SLB | Leo Chenal |
| LCB | Trent McDuffie |
| SS | Jaden Hicks |
| FS | Bryan Cook |
| RCB | Jaylen Watson |
| NB | Chamarri Conner |
Specialists
| Position | Player |
| PK | Harrison Butker |
| P/H | Matt Araiza |
| LS | James Winchester |
| PR | Nikko Remigio |
| KR | Nikko Remigio |
Philadelphia Eagles Starting Lineup
Offense
| Position | Player |
| QB | Jalen Hurts |
| RB | Saquon Barkley |
| WR | A.J. Brown |
| WR | DeVonta Smith |
| WR | Jahan Dotson |
| TE | Grant Calcaterra |
| LT | Jordan Mailata |
| LG | Landon Dickerson |
| C | Cam Jurgens |
| RG | Tyler Steen |
| RT | Lane Johnson |
Defense
| Position | Player |
| LDE | Moro Ojomo |
| NT | Jordan Davis |
| RDE | Jalen Carter |
| WLB | Nolan Smith Jr. |
| LILB | Zack Baun |
| RILB | Jihaad Campbell |
| SLB | Jalyx Hunt |
| LCB | Adoree’ Jackson |
| SS | Reed Blankenship |
| FS | Andrew Mukuba |
| RCB | Quinyon Mitchell |
| NB | Cooper DeJean |
Specialists
| Position | Player |
| PK | Jake Elliott |
| P/H | Braden Mann |
| LS | Charley Hughlett |
| PR | Jahan Dotson |
| KR | Will Shipley |
Chiefs vs Eagles Depth Chart for Week 2
Kansas City Chiefs Depth chart
Offense
| Pos | 1st | 2nd |
| QB | Patrick Mahomes | Gardner Minshew |
| RB | Isiah Pacheco | Kareem Hunt |
| WR | Hollywood Brown | Tyquan Thornton |
| WR | JuJu Smith-Schuster | Jason Brownlee |
| WR | Xavier Worthy (Out) | Jalen Royals |
| TE | Travis Kelce | Noah Gray |
| LT | Josh Simmons | Wanya Morris |
| LG | Kingsley Suamataia | Mike Caliendo |
| C | Creed Humphrey | Hunter Nourzad |
| RG | Trey Smith | Ethan Driskell (O) |
| RT | Jawaan Taylor | Jaylon Moore |
Defense
| Pos | 1st | 2nd |
| LDE | George Karlaftis | Charles Omenihu |
| LDT | Chris Jones | Jerry Tillery |
| RDT | Omarr Norman-Lott | Derrick Nnadi |
| RDE | Mike Danna | Ashton Gillotte |
| WLB | Drue Tranquill | Jeffrey Bassa |
| MLB | Nick Bolton | Jack Cochrane |
| SLB | Leo Chenal | Cooper McDonald |
| LCB | Trent McDuffie | Nazeeh Johnson (IR) |
| SS | Jaden Hicks | Deon Bush (IR) |
| FS | Bryan Cook | Kevin Knowles |
| RCB | Jaylen Watson | Kristian Fulton |
| NB | Chamarri Conner | — |
Philadelphia Eagles Depth chart
Offense
| Pos | 1st | 2nd |
| QB | Jalen Hurts | Tanner McKee (Q) |
| RB | Saquon Barkley | Will Shipley (O) |
| WR | A.J. Brown | John Metchie III |
| WR | DeVonta Smith | Darius Cooper |
| WR | Jahan Dotson | Johnny Wilson (IR) |
| TE | Dallas Goedert (O) | Grant Calcaterra / Kylen Granson |
| LT | Jordan Mailata | Fred Johnson |
| LG | Landon Dickerson | Brett Toth |
| C | Cam Jurgens | Drew Kendall |
| RG | Tyler Steen | Matt Pryor |
| RT | Lane Johnson | Cameron Williams (IR) |
Defense
| Pos | 1st | 2nd |
| LDE | Moro Ojomo | Byron Young |
| NT | Jordan Davis | Ty Robinson |
| RDE | Jalen Carter | Za’Darius Smith |
| WLB | Nolan Smith Jr. | Za’Darius Smith |
| LILB | Zack Baun | Smael Mondon Jr. |
| RILB | Jihaad Campbell | Jeremiah Trotter Jr. |
| SLB | Jalyx Hunt | Joshua Uche |
| LCB | Adoree’ Jackson | Jakorian Bennett |
| SS | Reed Blankenship | Marcus Epps |
| FS | Andrew Mukuba | Sydney Brown |
| RCB | Quinyon Mitchell | Kelee Ringo |
| NB | Cooper DeJean | Mac McWilliams |
How To Watch Chiefs vs Eagles
The Chiefs and Eagles square off on Sunday, Sept. 14, 2025 at 4:25 p.m. ET in GEHA Field at Arrowhead Stadium (Kansas City). The game will be broadcast on FOX and streamed on FOX digital partners stream options.
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