While there are many exciting matchups in Week 1 of the NFL season, Los Angeles Rams vs Houston Texans is one many fans are looking forward to. It is a game that features two teams with high expectations and with quarterbacks in two very different stages of their careers. Here we will take a look at everything you need to know about this matchup, which is slated to begin at 4:25 p.m. ET on Sunday.
It’s here and it’s glorious 🥹 pic.twitter.com/lZgCj8fvTI
— NFL (@NFL) September 6, 2025
Los Angeles Rams vs Houston Texans Key Players to Watch
The Los Angeles Rams vs the Houston Texans matchup is a game featuring two QBs at different stages of their careers. Despite that, there are high expectations for both of them. For the Rams, they have Matthew Stafford, who is getting towards the end of his career. Despite that, he has still played at an elite level in recent seasons when healthy. He will be trying to help the Rams reach the playoffs as they look to extend their contention window.
For the Texans, they are hoping their third-year QB, CJ Stroud, can bounce back. As a rookie, Stroud exploded onto the scene, similar to Jayden Daniels last year. There were expectations that he would take a step back in his second year in the league, but he took a bit of a step back. While the Texans still made the playoffs, it was not the season they hoped to have. Texans fans are hoping Stroud can get back on track this year, starting with a big performance against the Rams.
Los Angeles Rams vs Houston Texans Odds and Betting Lines
Odds via FanDuel.
- Moneyline: LA Rams (-168), Houston Texans (+140)
- Spread: LA Rams -3 points (-118), Houston Texans (+3)
- Total: Over 43.5 points (-104), Under 43.5 points (-118)
Picks and Predictions for Los Angeles Rams vs Houston Texans
This is not an easy matchup to predict, but in Week 1, we give the edge to the Rams. If this were later in the season, the Texans might get the edge. That is because the biggest obstacle expected to face the Rams this season is Matthew Stafford’s health. He has struggled with back issues this offseason, but he will never be healthier this season than he is in Week 1.
So, we are predicting a healthy LA squad to defeat Houston on Sunday.
Best Bet: C.J. Stroud & Matthew Stafford to Each Record 15+ Passing Yards in Each Quarter (+105)
Read More:
- Matthew Stafford College Stats: From SEC Liability to SEC Leader, Georgia QB Set the Standard for Future Bulldogs
- C.J. Stroud College Stats: Ohio State Buckeyes Star Turned Houston Texans Record-Holder
- ‘That Running Back Nice’ – Cam Skattebo Draws Praise From Former Ohio State QB CJ Stroud
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