Week 2 of the 2025 college football season brings some high-profile matchups and nationally ranked games. From the Border Showdown to the nightcap in Norman, fans will be in for an exciting weekend of football. Below are the top 10 matchups heading into week 2.
Top 10 Week 2 College Football Games To Watch
1. #14 Michigan at #18 Oklahoma
Bryce Underwood heads into his first true road test as his Wolverines take on the Sooners, led by John Mateer. The Sooner quarterback threw for 392 yards in his debut, and Underwood accounted for 251 through the air. Both teams will be looking for a high-profile win to bolster their playoff resumes in the game of the weekend.
2. Baylor at #16 SMU
The Metroplex rivalry reignites as SMU enters ranked and on a 15–1 run in Dallas since 2022. Baylor will rely on its defensive front to disrupt Rhett Lashlee’s fast-paced attack, but oddsmakers have SMU as a field-goal favorite in what should be an offensive showcase.
3. Iowa at #22 Iowa State
The Cy-Hawk rivalry will be in Ames this year, where Rocco Becht looks to keep the Cyclones on track after a 2-0 start. The Hawkeyes will look for revenge after falling in last year’s thriller, 20-19.
4. USF at #15 Florida
The Gators are favored by nearly three touchdowns, but the Bulls have momentum after pulling off the first upset of the season against #25 Boise State. USF will look to keep the momentum going, while the Gators will try to take care of business before SEC play starts.
5. UCLA at UNLV
UCLA heads to Allegiant Stadium after falling to Utah in the opener. UNLV is 2–0 and looking to prove it can compete against Power Five opponents under Dan Mullen. The Rebels’ balanced run attack could make this a potential upset watch in Las Vegas.
6. #21 Ole Miss at Kentucky
Lane Kiffin’s Rebels, up to No. 21 after a 63–7 opener, are two-score road favorites behind freshman QB Austin Simmons. Kentucky, behind a balanced offense, will look to make some noise in an early SEC matchup.
7. Kansas at Missouri
The Boarder Showdown returns with two of the top performers in week 1. Beau Pribula threw for 283 yards, while Jaylon Daniels will lead an offense that averages 38.5 points per game. Missouri is favored by a touchdown in the week’s biggest rivalry game.
8. Vanderbilt at Virginia Tech
Diego Pavia has sparked Vanderbilt’s offense with 275 passing yards and three touchdowns in Week 1, setting up a test against a Virginia Tech defense still recovering from the Sunday loss against South Carolina. The Hokies are currently slight favorites, seemingly giving this matchup upset potential considering their short turn around time.
9. #11 Arizona State at Mississippi State
After a closer-than-expected win over Northern Arizona, Sam Leavitt and the Sun Devils will head to Starkville to take on Mississippi State. Jeff Lebby’s Bulldogs look to have a turnaround season, and a potential home upset could go a long way for the Bulldogs.
10. Boston College at Michigan
Boston College leans on quarterback Dylan Lonergan, who threw for 268 yards and four touchdowns in his debut, against a Michigan State defense that impressed in Week 1. Oddsmakers expect this game to be close, making this one of the best toss-up games for Week 2.
Bottom Line
From Michigan vs Oklahoma to rivalry games like Kansas vs Missouri, Week 2 has plenty of playoff-altering games to create a thrilling college football weekend.
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