The Browns vs. Panthers matchup is one of the most anticipated preseason matchups of the year. While the preseason does not count towards the NFL standings, it does give fans a glimpse into how each team could look heading into the season. More importantly, it allows teams and fans to get a look at young players and recent draft picks before regular-season action.
This game is so highly anticipated because quarterback Shedeur Sanders is projected to start for the Cleveland Browns. While that is one story, there are many things to look forward to in this matchup. Here is a full preview for the Cleveland Browns’ matchup against the Carolina Panthers, which begins at 7 p.m. ET.
Browns vs Panthers Projected Starters
The biggest story heading into this game is the fact that QB Shedeur Sanders is starting. It will be a tough matchup for Sandes as the Browns will be resting most of their projected starters, according to Sports Betting Dime. He will play behind a backup offensive line and throw to second and third-string receivers. On the defensive side of the ball, Myles Garrett and the rest of the defensive starters will sit. However, it is up in the air if first-round defensive tackle Mason Graham will play.
gameday mood pic.twitter.com/kLGE1Enb0k
— Cleveland Browns (@Browns) August 8, 2025
Conversely, the Panthers are expected to play their offensive and defensive starters. QB Bryce Young is expected to take snaps, along with other key Panthers players, including first-round wide receiver Tetairoa McMillan.
Browns vs. Panthers Odds
Carolina is the favorite heading into the game, according to FanDuel.
- Moneyline: Cleveland (+220), Carolina (-270)
- Spread: Cleveland +6.5 (-120), Carolina -6.5 (+100)
- Total: Over 33.5 points (+100), Under 33.5 points (-120)
Browns vs Panthers Key Matchups
The key matchup of the game will be the QB battle. All eyes will be on Shedeur Sanders as he gets his first NFL action. He will be directly compared to Carolina QB Bryce Young, who is heading into his third NFL season. Young struggled early in his career but had a strong finish to last season.
Browns vs. Panthers Prediction
The Carolina Panthers should be the clear pick to win. While there is a lot of hype around Shedeur Sanders, it could be a tough night for him. With the Browns resting their starters and the Panthers playing them, fans should expect a dominant win from Carolina.
Browns vs Panthers Picks
Here are some of our picks for bets fans can place heading into this game. The odds are provided by FanDuel.
- Carolina Panthers 2+ Passing Touchdowns (+188)
- First Scoring Play: Carolina Panthers – TD (+180)
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