This has been a very rough start to the season for the San Francisco 49ers after stars like George Kittle, Brandon Aiyuk and Jauan Jennings were placed on the injured list. Now, QB1 Brock Purdy will be among them as the Niners’ injury problems escalated.
From @GMFB: #Commanders QB Jayden Daniels (wrist) is off the injury report, while #49ers QB Brock Purdy is out 2-5 weeks with a turf toe variant, sources say. pic.twitter.com/xQPT3Jm3cS
— Ian Rapoport (@RapSheet) September 11, 2025
The 49ers won against the Seattle Seahawks in Week 1 but it costed them big as they will be very banged up heading into Week 2 against the New Orleans Saints. Purdy is expected to miss two-to-five weeks thanks to a turf toe injury, and this has many fans talking about how injury prone the 49ers have been.
“49ers have the most injuries every single year,” one fan pointed out.
“HOW LONG TIL WE GET A VAX FOR THIS TURF TOE VARIANT?!?!” asked one commenter.
“Know season has truly started when key 49ers are sidelined,” said another X user.
“lol niners thought they was making the playoffs 😂😂😂u host the bowl u will have a horrible season,” another person added.
“Daniels is back just in time to watch his own team collapse without him.,” jested another one.
“Mac Jones will be needed to make sure the Niners don’t fall into a hole to start the season with the news of Brock Purdy’s injury and absence,” noted one person.
Because of the many injuries the team has suffered, several players have been brought in for tryouts, including TE Zach Davidson, TE Peyton Hendershot, TE Nick Muse, TE Messiah Swinson and QB Mike White. The 49ers also signed kicker Eddy Piñeiro.

Brock Purdy, Several Others Did Not Report to 49ers Practice
San Francisco 49ers’ injury problems were made clear as the team went to practice, with several big names not being able to work out due to injury, including Brock Purdy himself. He is not just dealing with an injured toe, but also has some issues with his left shoulder.
Meanwhile, DE Yetur Gross-Matos also missed Wednesday’s practice, this time because of a knee injury, while WR Jauan Jennings was also out with a shoulder injury. RB Christian McCaffrey was listed as resting his calf while T Trent Williams was listed as resting his knee. G Ben Bartch, RB Jordan James and WR Jordan Watkins had limited participation in the team’s practices.
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