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    Louisville vs. Boston College Prediction: Can Thomas Castellanos Run Past the Cardinals?

    Our Louisville vs. Boston College prediction takes a closer look at one of the most intriguing weeknight matchups in the ACC this season.

    The ACC is increasingly resembling the Big 12—a competitive conference filled with solid teams that can beat each other any given week. This week’s conference schedule is a perfect example: four of the seven ACC matchups have spreads within a single score, while two others are just into double digits.

    This sets up an intriguing Friday showdown between two 4-3 teams, as the Louisville Cardinals face off against the Boston College Eagles. Both teams are 2-3 in their last five games, making this Louisville vs. Boston College prediction one to watch closely.

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    Louisville vs. Boston College Betting Preview

    All Louisville vs. Boston College odds are from DraftKings Sportsbook and are correct as of Thursday, Oct. 24, 2024. The CFN Spread comes from College Football Network’s Football Playoff Meter.

    • CFN FPM Spread
      Louisville -4
    • Spread
      Louisville -7.5
    • Moneyline
      Louisville -285, Boston College +230
    • Over/Under
      53.5 points
    • Game Time
      Oct. 25, 7:30 p.m. ET
    • Location
      Alumni Stadium | Chestnut Hill, Mass.
    • Predicted Weather at Kick
      52 degrees, clear, seven mph winds
    • How To Watch
      ESPN2

    The spread is currently Louisville -7.5, as the Cardinals are almost universally seen as the better of the two teams. The public originally bet this down slightly, as the line was posted at -7 and moved to -6.5, but now sits at -7.5. With a total of 53.5 points, Vegas’ numbers imply a score close to 30-23 in favor of Louisville.

    MORE: CFN Betting Parlay Calculator

    Louisville’s Winning Probability

    FPM is close to the spread here, giving the Cardinals a 61.9% chance to win the game, translating to an implied spread of about 6.5 points in favor of Louisville. The Cardinals have a wide range of outcomes this season, as they’re slight favorites in three of five remaining games.

    • at Boston College: 61.9%
    • at Clemson: 20.7%
    • at Stanford: 77.4%
    • vs. Pittsburgh: 54.3%
    • at Kentucky: 50.8%

    Boston College’s Winning Probability

    FPM is slightly higher on Boston College in this one, as the metric has them as four-point underdogs. The Monarchs have a 38.1% chance to win the game. The Eagles will be underdogs in four of their remaining five games.

    • vs. Louisville: 38.1%
    • vs. Syracuse: 47.2%
    • at SMU: 25.1%
    • vs. North Carolina: 67.7%
    • vs. Pittsburgh: 39.4%

    Prediction for Louisville vs. Boston College

    There are a ton of factors at play here that could point you in either direction, from underlying numbers to matchups to narrative.

    On one hand, you have the home/road splits for these teams, as Boston College is 3-0 this season at home, while Louisville has benefitted from five home games, going 1-1 in their only two games away from L&N Federal Credit Union Stadium.

    Then there’s each team’s recent play. Even though each team is 2-3 in their last five, they’ve gotten there in very different ways.

    Louisville is 1-3 in one-score games this season, with losses to three teams currently ranked in the AP Top 25.

    Boston College is 2-1 in one-score games after squeaking out home wins against Michigan State and Western Kentucky and getting a late touchdown against Missouri to make the score of a game well-in-hand look closer.

    What I’m most interested in, though, is one particular matchup.

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    The Boston College quarterback was third in the ACC in rushing last season, first among quarterbacks. But this year, he’s failed to reach 20 yards on the ground in five of seven games in Bill O’Brien’s pro-style system.

    Louisville has been awful at stopping dual-threat quarterbacks from running. In fact, last week’s loss to Miami was the first FBS game in which an opposing quarterback didn’t lead his team in rushing against the Cardinals. Even then, it was Cam Ward’s 22-yard scramble on 3rd-and-17 that ultimately doomed Louisville.

    The question is: Can (or will) Thomas Castellanos run on Louisville’s defense?

    Boston College has some pieces on offense, but the Eagles have scored between 14 and 28 points against FBS opposition this year.

    Louisville is a better team than Boston College, and I trust Jeff Brohm in a close game more than Bill O’Brien (Brohm was 5-1 last season in one-score games, and I think Louisville’s struggles in that department this year are mostly misfortune).

    That being said, I like the Eagles to cover at home in a low-scoring game. If you can find Boston College +7, I’d feel even better. I like Louisville outright, so this should be a close game. In fact, I’m completely in agreement with the FPM.

    Prediction: Louisville 28, Boston College 24

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