A rematch of the 2024 College Football National Championship Game. An all-ranked SEC matchup. A Group of Five frontrunner looking to add another Power Four scalp to the resume. There are storylines everywhere you look in college football Week 6, with some games that appear just too tight to call, but our college football predictions for Week 6 light the way.
We compiled our college football predictions for Week 5 using the College Football Network Playoff Predictor, and you can too! Predict a conference, predict every game, or simulate the entire season to discover which 12 teams will make the 2024-2025 College Football Playoff. Get started right now!
Texas State vs. Troy Prediction
- Prediction: Texas State 38, Troy 19
- Betting Lines: Texas State -14.5
- TV Channel: ESPNU
Sam Houston vs. UTEP Prediction
- Prediction: Sam Houston 31, UTEP 17
- Betting Lines: Sam Houston -10.5
- TV Channel: CBS Sports Network
Jacksonville State vs. Kennesaw State Prediction
- Prediction: Jacksonville State 10, Kennesaw State 14
- Betting Lines: Jacksonville State -14
- TV Channel: CBS Sports Network
Houston vs. TCU Prediction
- Prediction: Houston 10, TCU 26
- Betting Lines: TCU -17
- TV Channel: ESPN
Michigan State vs. Oregon Prediction
- Prediction: Michigan State 10, Oregon 27
- Betting Lines: Oregon -24
- TV Channel: FOX
Syracuse vs. UNLV Prediction
- Prediction: Syracuse 33, UNLV 20
- Betting Lines: UNLV -4.5
- TV Channel: FS1
UCLA vs. Penn State Prediction
- Prediction: UCLA 14, Penn State 30
- Betting Lines: Penn State -28
- TV Channel: FOX
Missouri vs. Texas A&M Prediction
- Prediction: Missouri 31, Texas A&M 16
- Betting Lines: Texas A&M -1
- TV Channel: ABC
SMU vs. Louisville Prediction
- Prediction: SMU 10, Louisville 20
- Betting Lines: Louisville -7
- TV Channel: ESPN
Purdue vs. Wisconsin Prediction
- Prediction: Purdue 19, Wisconsin 14
- Betting Lines: Wisconsin -12
- TV Channel: Big Ten Network
UMass vs. Northern Illinois Prediction
- Prediction: UMass 16, Northern Illinois 33
- Betting Lines: Northern Illinois -17.5
- TV Channel: CBS Sports Network
Boston College vs. Virginia Prediction
- Prediction: Virginia 17, Boston College 30
- Betting Lines: Virginia -3.5
- TV Channel: ACC Network
Pittsburgh vs. North Carolina Prediction
- Prediction: Pittsburgh 19, North Carolina 21
- Betting Lines: Pittsburgh -2.5
- TV Channel: ESPN2
Wake Forest vs. NC State Prediction
- Prediction: Wake Forest 10, NC State 23
- Betting Lines: NC State -5.5
- TV Channel: The CW Network
Navy vs. Air Force Prediction
- Prediction: Navy 31, Air Force 20
- Betting Lines: Navy -8.5
- TV Channel: CBS
Army vs. Tulsa Prediction
- Prediction: Army 24, Tulsa 14
- Betting Lines: Army -11
- TV Channel: ESPNU
Tulane vs. UAB Prediction
- Prediction: Tulane 33, UAB 15
- Betting Lines: Tulane -15
- TV Channel: ESPN+
Western Michigan vs. Ball State Prediction
- Prediction: Western Michigan 13, Ball State 24
- Betting Lines: Western Michigan -7.5
- TV Channel: ESPN+
Iowa vs. Ohio State Prediction
- Prediction: Iowa 20, Ohio State 34
- Betting Lines: Ohio State -20.5
- TV Channel: CBS
Auburn vs. Georgia Prediction
- Prediction: Auburn 14, Georgia 31
- Betting Lines: Georgia -23.5
- TV Channel: ABC
Ole Miss vs. South Carolina Prediction
- Prediction: Ole Miss 35, South Carolina 24
- Betting Lines: Ole Miss -9
- TV Channel: ESPN
Indiana vs. Northwestern Prediction
- Prediction: Indiana 40, Northwestern 24
- Betting Lines: Indiana -13.5
- TV Channel: Big Ten Network
Temple vs. UConn Prediction
- Prediction: Temple 18, UConn 34
- Betting Lines: UConn -14
- TV Channel: CBS Sports Network
Virginia Tech vs. Stanford Prediction
- Prediction: Virginia Tech 39, Stanford 20
- Betting Lines: Virginia Tech -6
- TV Channel: ACC Network
Appalachian State vs. Marshall Prediction
- Prediction: Appalachian State 19, Marshall 35
- Betting Lines: Marshall -1.5
- TV Channel: ESPN+
Miami (OH) vs. Toledo Prediction
- Prediction: Miami (OH) 24, Toledo 39
- Betting Lines: Toledo -7
- TV Channel: ESPN+
Bowling Green vs. Akron Prediction
- Prediction: Bowling Green 19, Akron 10
- Betting Lines: Bowling Green -14.5
- TV Channel: ESPN+
East Carolina vs. Charlotte Prediction
- Prediction: East Carolina 27, Charlotte 13
- Betting Lines: East Carolina -8
- TV Channel: ESPNU
Rutgers vs. Nebraska Prediction
- Prediction: Rutgers 21, Nebraska 33
- Betting Lines: Nebraska -7
- TV Channel: FS1
West Virginia vs. Oklahoma State Prediction
- Prediction: West Virginia 17, Oklahoma State 31
- Betting Lines: Oklahoma State -4.5
- TV Channel: ESPN2
Alabama vs. Vanderbilt Prediction
- Prediction: Alabama 35, Vanderbilt 15
- Betting Lines: Alabama -24
- TV Channel: SEC Network
Colorado State vs. Oregon State Prediction
- Prediction: Colorado State 24, Oregon State 35
- Betting Lines: Oregon State -14
- TV Channel: The CW Network
Clemson vs. Florida State Prediction
- Prediction: Clemson 40, Florida State 28
- Betting Lines: Clemson -15.5
- TV Channel: ESPN
Utah State vs. Boise State Prediction
- Prediction: Utah State 21, Boise State 38
- Betting Lines: Boise State -26
- TV Channel: FS2
Old Dominion vs. Coastal Carolina Prediction
- Prediction: Old Dominion 19, Coastal Carolina 37
- Betting Lines: Coastal Carolina -5
- TV Channel: ESPN+
South Alabama vs. Arkansas State Prediction
- Prediction: South Alabama 29, Arkansas State 12
- Betting Lines: South Alabama -3.5
- TV Channel: ESPN+
James Madison vs. Louisiana-Monroe Prediction
- Prediction: James Madison 33, Louisiana-Monroe 10
- Betting Lines: James Madison -15.5
- TV Channel: ESPNU
Louisiana vs. Southern Miss Prediction
- Prediction: Louisiana 35, Southern Miss 17
- Betting Lines: Louisiana -14.5
- TV Channel: ESPN+
Tennessee vs. Arkansas Prediction
- Prediction: Tennessee 34, Arkansas 24
- Betting Lines: Tennessee -13.5
- TV Channel: ABC
Michigan vs. Washington Prediction
- Prediction: Michigan 28, Washington 14
- Betting Lines: Washington -2.5
- TV Channel: NBC
USC vs. Minnesota Prediction
- Prediction: USC 13, Minnesota 24
- Betting Lines: USC -9.5
- TV Channel: Big Ten Network
Baylor vs. Iowa State Prediction
- Prediction: Baylor 10, Iowa State 21
- Betting Lines: Iowa State -13
- TV Channel: FOX
Nevada vs. San Jose State Prediction
- Prediction: Nevada 24, San Jose State 36
- Betting Lines: San Jose State -7
- TV Channel: TruTV
UCF vs. Florida Prediction
- Prediction: UCF 36, Florida 17
- Betting Lines: Florida -1
- TV Channel: SEC Network
Duke vs. Georgia Tech Prediction
- Prediction: Duke 38, Georgia Tech 28
- Betting Lines: Georgia Tech -8
- TV Channel: ACC Network
Kansas vs. Arizona State Prediction
- Prediction: Kansas 24, Arizona State 38
- Betting Lines: Arizona State -3
- TV Channel: ESPN2
Hawaii vs. San Diego State Prediction
- Prediction: Hawaii 13, San Diego State 29
- Betting Lines: San Diego State -3
- TV Channel: CBS Sports Network
Miami (FL) vs. California Prediction
- Prediction: Miami (FL) 33, California 21
- Betting Lines: Miami (FL) -12.5
- TV Channel: ESPN
Texas Tech vs. Arizona Prediction
- Prediction: Arizona 10, Texas Tech 21
- Betting Lines: Arizona -5.5
- TV Channel: FOX
College Football Network has you covered with the latest from the ACC, Big Ten, Big 12, SEC, and every Group of Five conference and FBS Independent program.